UTI Flashcards
When to treat asymptomatic bacteruria
- Pregnant women (4-7 days)
- Undergoing endoscopic urologic procedure (1-2 doses)
- Renal transplant recipients in first 30 days post transplant
UA - nitrite positive indicates what bacteria
E. coli
Proteus
Klebsiella
UA with casts indicates what
pyelonephritis
Uncomplicated cystitis recommended therapy
- Bactrim DS BI x3 days (avoid if resistance >20% or used for UTI in past 3 months)
- Nitrobid 100mg BID x5 days (avoid CrCl <30)
- Fosfomycin 3gm x1
Uncomplicated cystitis alternative therapy
- B-lactams x5-7 days (augmentin, cefdinir, cefaclor, cephalexin, cefpodoxime)
- FQ (cipro or levo) x3 days
Uncomplicated pyelonephritis outpatient therapy
- Bactrim DS BID x14 days
- Levaquin 750mg x5 days or cipro 500mg BID x7 days
- B lactams (augmentin, cefdinir, cefaclor, cephalexin, cefpodoxime) x10-14 days
Uncomplicated pyelonephritis outpatient therapy if uropathogen resistance >10%
Initial dose of IV, long-acting B lactam or once-daily aminoglycoside
Complicated UTI outpatient therapy
- Bactrim DS BID x7-14 days
- Levaquin 750mg daily x5 days or cipro 500mg BID x7 days
- B lactams x7-14 days (augmentin, cefdinir, cefaclor, cephaexin, cefpodoxime)
Complicated UTI Inpatient therapy
Ceftriaxone, FQ, aminoglycoside x5-14 days
When anti-pseudomonal B lactam needed for complicated UTI inpatient
Recent hospitalization
Urinary catheter
Living in nursing home
Complicated UTI
- Males
- Hospital acquired
- Pregnancy
- Anatomic abnormality of urinary tract
- Poorly controlled diabetes
- Recent antimicrobial use
- Indwelling catheter
- Recent urinary tract instrumentation
- Immunosuppression
UTI in pregnancy therapy
- Augmentin x3-7 days
- Nitrofurantoin x5-7 days (avoid first trimester)
- Cephalexin or cefpodoxine x3-7 days
- Fosfomycin
Avoid these ABX for pregnant women
- FQs
- Tetracyclines
- Aminoglycosides
- Bactrim (especially late 3rd trimester)
Treatment duration for UTI relapse
-Infection with same organism within 14 days of discontinuing antibiotics
May need longer (2 week) treatment but assess why the first med failed
UTI prophylaxis if 2 or fewer UTIs in 1 year
Patient-initiated therapy (3 day treatments)
Reassess need for ppx every 6-12 months