UTI Flashcards
Kidney Infections called
Pyelonephritis
Renal Abscess
Bladder Infection called
Cystitis
Highest rate of hospital acquired infection
Urinary Tract
Name 7 Factors which are Predisposing Factors Specific to
Female Sex Sex and Poor Voiding Congenital Abnormalities Stasis of Urine Foreign Bodies Oestrogen Deficiency in Postmenopausal Women Fistula between Bladder and Bowel
Why is female sex a predisposing factor specific to urinary tract
Short urethra
Which bacteria is most common Gram Neg UTI Organism
E Coli
Which bacteria is most common Gram Pos UTI Organism
Coagulase Neg Stayphylocci
Which organisms usually in UTI (4)
E Coli
Proteus
Klebsiella
Enteroccocus
Clinical Features of UTI in Children
Diarrhoea Excessive Crying Fever Nausea and Vomit Not Eating
Clinical Features of UTI in Adult
Flank Pain Dysuria Cloudy offensive Urine Urgency Chill Strangury Confusion
Clinical Features of Acute Pyelonephritis (5)
Pyrexia Poor Localisation Loin tenderness (Renal Angle) Signs of Dehydration Turbid Urine
Investigations for UTI
Mid Stream Urine
Urinalysis
Bacteruria >10.5
Culture and Sensitivity
What investigations may be useful for UTI in children or men or frequent UTI’s
Ultrasound
IVU
What study may rule out reflux and scarring in UTI
Isotope Study
Antibiotics for UTI
Amoxicillin, Cephalosporin, Trimethroprim
What is Reflux Nephropathy
UTI in Children
Tests for Reflux Nephropathy
Micturating Cystogram
Ultrasound
Biochemistry
Treat Reflux Nephropathy
Surgery
How much fluid should be taken in to prevent UTI
2/L a Day
Void every 2-3 Hours
What is inevitable with Indwelling Urinary Catheter
Colonisation
What does Bacteriuria need to be with UTI
> 10.5
Chronic Pylonephritis is what type of diagnosis
Radiological
which conditions associated with chronic pyelonephritis
Hypertension and CRF
what percentage of chronic pyelonephritis can progress to renal failure
15%
Schistosomiasis can cause which UTI
Cysitits
What percentage of Renal Blood Flow is Cardiac Output
20-25%
Resorption of fluid is diminished if what happens to fluid intake
increase then increase urine output
Which renal organ does not store urine
Ureters
As bladder increases pressure as it fills what happens to ureters
the ureters close off and stops reflux of urine
Normal Bacteriostatic properties of normal urinary tract
Low pH, High Osmolarity and High Ammonia (NH3) content of normal urine
Prostatic secretions are said to be
bacteriostatic
Urinary tract except for where is sterile
Terminal Urethra
Suprapubic aspirated of urine. is
sterile
Urine specimen is always
Contaminated
In Mid Stream Specimen Urine what happens to urethral flora
diminished but always present
Urethral Flora will always do what in culture
Grow
In Mid Stream Specimen Sample there is no such thing as
negative result
If MSSU Culture is 10.3-10.4 then what is the percentage chance of infection if no symptoms
50%
Route of UTI infection is almost always
ascending
Upper Urethral and Bladder Dilatation can lead to
Bilateral Hydroureter and eventually Chronic Renal Failure
Unilateral Hydroureter is at what level
of renal pelvis on 1 side only
Consequences of Obstruction
Proximal Dilatation
Infection
Increased Calculous Formation
What triad make up Obstruction in UTI
Infection
Calculi
Obstruction
Obstruction in Children always investigate when
1st presentation
Most important type of Obstruction in children
Vesicoureteric Reflux
What happens in Vesicoureteric Reflux
Decreased Angulation of Ureter into Bladder
Common cause of obstruction in men
Benign Prostatic hyperplasia
Common cause of obstruction in women
Uterine Prolapse
Spinal Cord/Brain Injury can lead to what happening regarding volume in bladder
High Residual Volume = Stasis
In females sex tends to move what up the urinary tract
Lower Urethral Flora
Why is diabetes a predisposition to UTI
Glucose in Urine
Poor Function of WBC
Acute Complication of UTI
Sepsis/Septic Shock
Calculi in UTI can lead to
Obstruction Hydronephrosis
Chronic Pyelonephritis can lead to
Hypertension and Chronic Renal Failure
A diagnosis of Urinary Tract infection needs
Microbiological evidence and symptoms/signs
Microbiological evidence needed for UTI
Bacterial count of 10.4 from MSSU with no more than two species of micro organisms
Orchitits is what
UTI of Testis
Pyelonephritis especially can lead to what complication
Sepsis
UTI can lead to what malignancy as complication
Squamous Cell Caricinoma
How to investigate Lower tract UTI
MSSU/CSU
Flow Study
Residual Bladder Scan
cystoscopy
how to investigate upper tract UTI
USS Kidneys
IVU/CT-KUB
MAG-3 Renogram
DMSA Scan
Is renal colic an emergency
Yes
is acute retention an emergency
yes
is chronic high pressure retention an emergency
yes
is testicular torsion an emergency
yes
is paraphimosis an emergency
yes
is priapism an emergency
yes
Essential Features of Acute Retention
Painful
Palpable Bladder
Inability to pee
Percussible Bladder
Which organisms are commonly associated with UTI (4)
E Coli
Klebsiella
proteus
Pseudomonas
UTI accounts for approx how much GP Consults
6%
Bacteruria in UTI is
The presence of bacteria in urine. Note that the anterior urethra is not sterile and the presence of urethral organisms in urine washed out during micturition is not bacteriuria.
Pyuria in UTI is
The presence of pus cells (actually neutrophil polymorphs) in significant quantities in urine. This represents an inflammatory response and is supportive evidence of the presence of
a UTI.
When to treat women with UTI
3 or more symptoms
MSU Sample is collected after first
10-20ml of stream has passed
What usually causes UTI in younger men
STI’s eg Chlamydia or Gonnorhoea
For Kidney UTI antibiotics should be given for
7 Days
Culture and Antibiotics should only be given with Catheter related infection when
Patient symptomatic
When to treat asymptomatic bacteriuria
Pregnant
Surgery
Evidence that asymptomatic bacteriuria in pregnancy associated with
Increased risk pyelonephritis and premature delivery
Textbook cause of Sterile Pyuria
Renal Tuberculosis but could be STI
How to test for Renal Tuberculosis
Three early morning urines for ZN Stain and TB
Patients with Chronic pyelonephritis may show what on radiology
Clubbing of Calyces with Scarring or Cortical Parenchyma
If ureters appear dilated on radiograph then what test should be done
micturating cystogram to detect VUR
When should urine cultures be taken
Dipstick Inconclusive for Women with Mild or limited symptoms
Suspected UTI in Men
Suspected Acute Pyelonephritis
Pregnant Women
After failed antibiotic
Recurrent UTI
Children with Suspected UTI
What is recurrent UTI defined as
> 2 UTI’s within 6 months or >3 UTIs in a year
Where should catheter specimens be obtained from in catheter related urinary infection
catheter sampling port
for children with UTI sampling do not use
Cotton Wool balls
Gauze
sanitary towels
for children with UTI sampling
Suprapubic Aspiration useful as no contamination
E coli UTI is linked to
p fimbriae
Staph Saprophyticus is a coagulase neg staph recognised as cause of UTI in
Sexually active women
Proteus in UTI produces which enzyme
Urease which splits urea to release ammonia
Urease and Urea do what to urine
Make it alkaline and encourage stone formation
Which organisms are more common in UTI in Hospital patients
Proteus
Klebsiella
Pseudomonas Spp
Presence of how many white blood cells in Microscopy of UTI is determined significant pyuria and thus significant inflammation
> 10 White Blood Cells
Trimethroprim or nitrofurantoin in UTI should not be used when
Pregnancy
Treatment for Lower UTI in Men
14 Days of Quinolone eg Ciprofloxacin
Acute Pyelonephritis Treatment
Ciprofloxacin for 7 Days
Treatment for pregnant UTI
Cephalexin
Nitrofurantoin could cause what in pregnant UTI at term
Neonatal Haemolysis