Kidneys in Systemic Flashcards
How are Diabetes and Renal related
Renal Hypertrophy and Glomerular Hypertension and Hyperfiltration
What happens in Diabetes and Renal with Albuminuria
Deposition of ECM leading to Glomerulosclerosis and Interstitial Fibrosis
what does GFR do in diabetes
Increases
Microalbuminuria classified as
20-200
Clinical neuphropathy classified as
Proteinuria >0.5
What happens to serum creatinine in Type 2 Diabetes
rises
Increasing proteinuria associated with declining
GFR
Diabetic Nephropathy is single commonest cause of
End Stage Renal Disease
What percentage of Lupus patients will get Lupus Nephritis
60%
what is lupus nephirits a form of
Immune mediated Glomerulonephritis
What features of Lupus Nephritis
Proteinuria Nephritic Syndrome Haemtaturia Red Cell Casts Elevated Creatinine
what is multiple myeloma
monoclonal proliferation of plasma cells
multiple myeloma is common in
elderly
myeloma presentation
increased ESR Anaemia weight loss fractures infection back pain
diagnosis myeloma
bone marrow aspirate >10% clonal plasma cells
serum paraprotein + immunoparesis
urinary bench jones protein
skeletal survey for lytic lesions
