Uterus and ovaries A&P, Pathophysiology Flashcards

1
Q

what is the isthmus

A

area where the wall of the tube is thickest

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2
Q

What is the functional outermost layer of the uterus

A

stratum functionalis

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3
Q

what is the base layer of the uterus

A

stratum basalis

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4
Q

what occurs when endometrial tissue is outside of the uterine cavity

A

endometriosis

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5
Q

what is endometriosis hallmarked by

A

dysmenorrhea, dyspareunia, infertility

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6
Q

what is adenomyosis

A

enlargement of the myometrium due to presence of endometrial glands in this layer of the uterus - essentially a form of endometriosis

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7
Q

what is the acronym for abnormal uterine bleeding

A

PALM-COEIN
PALM is the structural causes
COEIN is nonstructural

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8
Q

What does PALM-COEIN stand for

A

Polyps
Adenomyosis
Leiomyoma (aka fibroid)
Malignancy

Coagulopathy
Ovulatory dysfunction
Endometrial
Iatrogenic
Not otherwise classified

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9
Q

what is anovulatory cycle

A

no spike in LH or no ovulation there will be no corpus luteum - lack of progesterone

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10
Q

what can occur with anovulatory cycle

A

elevated estrogen can cause increased bleeding from change in vascular development of the endometrium

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11
Q

what is an overgrowth of the endometrial glands

A

endometrial hyperplasia

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12
Q

what patients do we see endometrial hyperplasia in more

A

older patients and obesity

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13
Q

what is the presentation of endometrial hyperplasia

A

abnormal uterine bleeding

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14
Q

what is an overgrowth of endometrial glands and stroma

A

endometrial polyps

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15
Q

where are endometrial polyps formed

A

around a vascular bed and will hang in a pedunculated fashion

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16
Q

what are leiomyomas

A

fibroids or myomas
similar to polyps but are arising from smooth muscle and fibroblasts

17
Q

what are the symptoms of leiomyomas

A

depend on size and location - may cause severe menorrhagia, menometrorrhagia, can become necrotic if they twist, found at infertility workup

18
Q

what is an ascending infection from vagina and cervix

A

pelvic inflammatory disease

19
Q

what can be included with pelvic inflammatory disease

A

salpingitis, endometriosis, myometritis, oophoritis, tubo-ovarian abscess

20
Q

what can result as of PID

A

development of long term consequences as a result of the scaring/inflammation

21
Q

what is the most common causative agent of PID

A

gonorrhea and chlamydia
-e.coli can be associated with post-menopausal women
often thought to be polymicrobial

22
Q

What is the most common sexually transmitted disease

A

Chlamydia trachomatis

23
Q

when assessing for chlamydia what is the lab test

A

only grows on living media

24
Q

What is the cycle of N.gonorrhea

A

binds to fallopian tubes - endotoxin destroys cilia of surrounding cells - taken into the cells via endocytosis - transported in via endocytotic vacuole (of host cell) in which it multip

25
Q

what is the presentation of gonorrhea

A

urethritis (dysuria, discharge)
can infect epididymis, prostate and rectum
septic arthritis: typically in only 1 or two joints

26
Q

What is inflammation of intrauterine lining that is most commonly associkated with PID

A

endometritis

27
Q

what is endometritis associated with

A

PID and transcervical procedures

28
Q

What is the inflammation of the fallopian tube

A

salpingitis

29
Q

What is tubo-ovarian abscess

A

complication of PID, develops in pts with salpingitis
inflammatory, infectious pathology with collection of purulent fluid within fallopian tube or ovary

30
Q

what is the presentation of tubo-ovarian abscess

A

acute pelvic/abdominal pain
fevers/chills
discharge
adnexal tenderness/mass

31
Q

what is hallmarked by ovarian cysts, obesity, alternation in menses, increased androgen production

A

polycystic ovarian syndrome

32
Q

What are some of the genetic links associated with PCOS

A

P450c alteration
LH receptor gene abnormalities
DENND1A alteration
Thyroid adenoma gene

33
Q

what occurs due to PCOS

A

incomplete ovulation
hirsutism
menorrhagia when menses occurs, dysmenorrhea as well
endometrial hyperplasia

34
Q

what are signs and symptoms of PCOS

A

irregular or prolonged periods
fluid filled sacs or cysts
growth of extra, unwanted hair
hair loss
excessive cramping and bloating during menstruation
acne and other skin problems
psychological stress and depression
fatigue
pelvic pain
rapid weight gain

35
Q

What is ovarian torsion

A

enlargement of ovary will cause twist around the ligament of ovary which encases the vascular supply
progression will -> arterial obstruction
necrosis = ischemia

36
Q

What side is ovarian torsion most common on

A

right side

37
Q

what is the presentation of ovarian torsion

A

severe, sudden onset of adnexal pain, vomitting