URT viral infections Flashcards
cause of croup
parainfluenza virus
Most common cause of cold
rhinovirus
URI virus transmission
aerosols
What is the first site of virus–> host interaction?
epithelial cells
What causes symptoms in viral resp. infections?
cytokine release from epithelial cells–> fever, aches etc.
Viruses that cause acute infection with replication confined to resp. mucosa
picornavirus (rhinovirus)
coronavirus
paramyxovirus (parainfluenza and RSV)
orthomyxovirus (influenza)
viruses that cause persistent replication on resp mucosal surface
EBV
adenovirus
papillomavirus
viruses that cause systemic replication (dissemination) after primary resp infection
paramyxovirus (mumps, measels) Herpesviruses (EBV, VZV, HHV6, CMV) Rubella Picornavirus (polio) bunya, areno, parvo, pox, reo viruses
coronavirus
negative ssRNA
cold like sx
some rare strains can cause lethal disease (SARS, MERS)
Myxoviruses
bind to mucin protein on RBCs
orthomyxoviridae
influenza A B and C
nuclear replication
neg. segmented ssRNA
enveloped
paramyxoviridae 3 genera
paramyxovirus morbillivirus peumovirus cytoplasmic replication non-segmented neg ssRNA enveloped
paramyxoviruses
mumps
parainfluenzavirus 1-4
newcastle disease virus
mobilliviruses
measels
rinderpest
canine distemper
pneumoviruses
RSV
What are some major contributors to the pathogenesis of influenza syndrome
desquamation of mucus-secreting and ciliated cells
interferon induction
T-cell responses
Antibody
RSV
croup peaks in winter starts like a cold in adults and infants only tx is steam and humidifiers complications: pneumonia, resp. distress
Adenovirus
widespread in nature icosahedral naked, DNA virus most people have been infected with at least 1 type by 15 most infections are asymptomatic infects resp, GI, and eye
adenovirus transmission
resp droplets fecal matter fomites close contact poorly sanitized
