URT viral infections

Question 1

cause of croup

Answer 1

parainfluenza virus

Question 2

Most common cause of cold

Answer 2

rhinovirus

Question 3

URI virus transmission

Answer 3

aerosols

Question 4

What is the first site of virus–> host interaction?

Answer 4

epithelial cells

Question 5

What causes symptoms in viral resp. infections?

Answer 5

cytokine release from epithelial cells–> fever, aches etc.

Question 6

Viruses that cause acute infection with replication confined to resp. mucosa

Answer 6

picornavirus (rhinovirus)
coronavirus
paramyxovirus (parainfluenza and RSV)
orthomyxovirus (influenza)

Question 7

viruses that cause persistent replication on resp mucosal surface

Answer 7

EBV
adenovirus
papillomavirus

Question 8

viruses that cause systemic replication (dissemination) after primary resp infection

Answer 8

paramyxovirus (mumps, measels)
Herpesviruses (EBV, VZV, HHV6, CMV)
Rubella
Picornavirus (polio)
bunya, areno, parvo, pox, reo viruses

Question 9

coronavirus

Answer 9

negative ssRNA
cold like sx
some rare strains can cause lethal disease (SARS, MERS)

Question 10

Myxoviruses

Answer 10

bind to mucin protein on RBCs

Question 11

orthomyxoviridae

Answer 11

influenza A B and C
nuclear replication
neg. segmented ssRNA
enveloped

Question 12

paramyxoviridae 3 genera

Answer 12

paramyxovirus
morbillivirus
peumovirus
cytoplasmic replication
non-segmented neg ssRNA
enveloped

Question 13

paramyxoviruses

Answer 13

mumps
parainfluenzavirus 1-4
newcastle disease virus

Question 14

mobilliviruses

Answer 14

measels
rinderpest
canine distemper

Question 15

pneumoviruses

Answer 15

RSV

Question 16

What are some major contributors to the pathogenesis of influenza syndrome

Answer 16

desquamation of mucus-secreting and ciliated cells
interferon induction
T-cell responses
Antibody

Question 17

RSV

Answer 17

croup
peaks in winter
starts like a cold in adults and infants
only tx is steam and humidifiers
complications: pneumonia, resp. distress

Question 18

Adenovirus

Answer 18

widespread in nature
icosahedral naked, DNA virus
most people have been infected with at least 1 type by 15
most infections are asymptomatic
infects resp, GI, and eye

Question 19

adenovirus transmission

Answer 19

resp droplets
fecal matter
fomites
close contact 
poorly sanitized