Haemophilus and Bordetella Flashcards
reservoir for haemophilus and bordetella?
Human Restricted
How do you culture haemophilus and bordetella?
require factors X (heme) and V (NAD)
Transmission for haemophilus and bordetella?
resp. droplets
mostly pediatric contagious resp. infection
How do you treat and prevent haemophilus and bordetella?
vaccines available
tx: abx and supportive care
haemophilus are gram _____, ________ shaped.
gram neg
pleomorphic: may be cocci or rods
What is the most pathogenic strain of haemophilus and what makes it so pathogenic?
HiB, encapsulated–> immune evasion
can cause lethal meningitis
bacteremia quickly follows URI and underlies all invasive disease: meningitis, cellulitis, epiglottitis, septic arthritis
What are the less pathogenic types of haemophilus?
NTHi: unencapsulated
vaccine available
may be normal flora
can cause neonatal and postpartum sepsis, CF pneumonia, systemic complications after untreated local mucosal infections, esp with predisposing factors
Virulence factors for NTHi?
no capsule
IgA protease
pili
adhesins like HiB
B. pertussis virulence factors?
filamentous hemagglutinin pilus
pertussis toxin
exotoxin that causes ciliary stasis
How contagious is B. pertussis? incidence and mortality?
highly
incidence and mortality increasing because of inadequate vaccine coverage
What causes the distinctive cough in pertissus?
ciliary stasis from exotoxin
Does pertussis cause bacteremia?
no, good prognosis
What blood test finding is helpful in diagnosing pertussis?
leukocytosis
Bordetella pertussis is gram ______, _____ shaped
short gram negative rods
