Enteric Viruses

Question 1

T/F: Picornaviruses, noroviruses, rotaviruses are:
1- enveloped
2- large
3- icosahedral
4- RNA
5- environmentally rugged
6- respiratory transmission

Answer 1

1- False! they are naked 
2- False! they are small
3- true
4- true
5- true 
6-FALSE: fecal-oral

Question 2

Enteroviruses are a subset of ______ that cause GI infection

Answer 2

picornaviruses

Question 3

What do Picornaviruses, noroviruses, rotaviruses cause? What is the common course of disease? what is the most common complication?

Answer 3

All three cause self-limited GI illness, usually resolves without medical intervention or complication
Most common complications are dehydration w/ roto (watch for pediatric anorexia+lethargy), CNS infection w/ entero.

Question 4

Where do enteroviruses replicate?

Answer 4

main replication is in the gut
but also cause viremia with replication in regional lymph nodes and can rarely penetrate the CNS, thus infection is usually mild but occasionally devastating

Question 5

What patient population is more commonly affected by enteric viruses?

Answer 5

pediatric, the younger the worse

Question 6

What syndromes does coxsackie A cause?

Answer 6

Herpangina
Hand, Foot, and Mouth Disease
Acute Hemorrhagic Conjunctivits
*usually less severe than coxsackie B

Question 7

What syndromes does coxsackie B cause?

Answer 7

myocarditis
pleurodynia
meningitis
*there is overlap between coxsackie A and B sx

Question 8

poliovirus is a ______virus?_____stranded, _____-sense, _NA genome, ________ icosahedral capsid, environmentally ________.

Answer 8

picornavirus (enterovirus subtype)
single stranded
positive sense
RNA
naked
rugged

Question 9

What is the optional and possible future treatment for coxsackie?

Answer 9

pleconaril

Question 10

How do you test for enteric viruses?

Answer 10

Use lumbar puncture to keep tabs on known bad enteroviruses (polio, anything causing aseptic meningitis) and take samples (swabs, blood) to PCR-differentiate any usually-harmless enteroviruses (HFMD, herpangina) that are causing concern

Question 11

Name this syndrome (hint: caused by coxsackie)

• acute febrile illness
• small vesicular or ulcerative lesions of posterior oropharyngeal structures
• usually pediatric
• mild, self-limited

Answer 11

herpangina

Question 12

Name this syndrome (hint: caused by coxsackie)

• acute febrile illness
• peds
• mild- self-limited
• vesicular eruptions in mouth, hands, feet, buttocks, genetalia

Answer 12

hand, foot, and mouth disease

-may cause dehydration because it is so painful to drink

Question 13

Name this syndrome (hint: caused by coxsackie)

• rapid onset
• young teens
• eye affected
• very unpleasant

Answer 13

acute hemorrhagic conjunctivitis

Question 14

What is pleurodynia?

Answer 14

caused by coxsackie B
infection of striated muscle in chest
-suden lancinating attacks of chest pain