Uro and optho Flashcards
what antibiotics can have renal effects in horses
Aminoglycoside like Gentamicin
Oxytet
What reagent strip result is false in horse urinalysis?
Protein due to their alkaline urine
What two compounds measure GFR
Creatinine and urea
When does AKI commonly occur? and what happens?
Hospitalised horses show a marked decrease in GFR
What can cause Haemodynamic AKI?
Conditions causing sustained marked hypotension like enterocolitis, septic shock, Haemorrhagic shock, coagulopathy
What can cause nephrotoxic AKI?
Antibiotics (Aminoglycosides + Oxytet)
NSAIDs
Myopathies and haemolysis (Myoglobin and Hb cause tubular damage)
Vitamin D
What blood parameter is increased with ARF?
Creatinine
What USG are ARF patients typically?
Isosthenuric
Hyposthenuric if pre-renal
Ultrasound appearance of AKI kidneys
Increased cortico-medullary definition
Enlarged kidneys
Common immune complexes that can cause CKD by glomerular disease?
Streptococcus complex deposition
Also equine infectious anaemia
Common signs of CRF?
PU/PD, weight loss, ventral oedema
Dietary management of CKD:
- Balanced protein to maintain weight
- Low salt
- Low carbohydrates
- Encourage diuresis
Brown/red urine, Heam +ive, once spun has clear supernatant =
Whole blood so haematuria
Common cause of Myoglobinuria
Myopathy => myoglobin in blood causes tubular damage => myoglobin enters urine
Common cause of haemoglobinuria
Intravascular haemolysis
Causes of haematuria
Exercise-induced, uroliths, UTI, pyelonephritis, neoplasia
What are the 4 physiological causes of PUPD
Excess diet protein
excess diet salt
High environmental temperature
Drugs like glucocorticoids, alpha-2, diuretics
Most common cause of PUPD in adult horses
Is it not PPID??
What 3 mechanics cause PUPD in PPID
- osmotic dieresis due to high plasma glucose
- ADH antagonism by cortisol
- Adenoma growth may effect ADH storage and production in pituitary gland
What are the two forms of diabetes insidious
- Neurogenic (inadequate ADH secretion)
- Nephrogenic (decreased sensitivity)
Signs of DI after water deprivation test:
Failure to concentrate urine
How does cortisol cause PUPD in EMS and PPID?
High cortisol = antagonises insulin = higher blood glucose = osmotic dieresis ve
also antagonises ADH
Value for Hypothosthenuria? and what does it indicate?
USG <1.008
Kidney actively excreting water
DI and APP
Value for Isosthenuria? and what does it indicate?
USG 1.008-1.014
Kidney neither concentrating or diluting
CRF