Urinary Systems - Most important Flashcards
The kidneys - What do they do?
Function of the kidneys
- Regulation of blood ionic composition
- Regulation of blood volume
- Regulation of blood pressure
- Regulation of blood pH
- Regulation of red blood cell production
- Vitamin D synthesis
- Excretion of wastes and foreign substances
Explain to different ways of purifying the blood in case of renal failure.
- Hemodialysis
- CAPD - continuous ambulatory peritoneal dialysis
Dialysis is a process of purifying the blood of a person whose kidneys are not working normally. It achieves the removal of waste products such as creatinine and urea and free water from the blood when the kidneys are in a state of renal failure.
There are two kinds of dialysis. In hemodialysis, blood is pumped out of your body to an artificial kidney machine, and returned to your body by tubes that connect you to the machine. In peritoneal dialysis, CAPD, the inside lining of your own belly acts as a natural filter. Wastes are taken out by means of a cleansing fluid called dialysate, which is washed in and out of your belly in cycles.
Name three Fluid compartments in the human body.
Fluid compartments
- Plasma
- Interstitial fluid
- Intracellular fluid
Buffers - what do they do?
Buffer systems
- Act quickly to temporarily bind H+
- Prevent rapid, drastic changes in the pH of body fluids.
There are three principal buffer systems:
- The protein buffer system
- The carbonic acid - bicarbonate buffer system
- The phosphate buffer system
Explain the Protein Buffer System.
Protein Buffer System
- Proteins are composed of amino acids and contain at least one carboxyl group (-COOH) and at least one amino group (-NH2 ).
- The carboxyl group releases H+ when pH rises. H+ is then able to react with any excess OH- in the solution to form H2O.
- On a fall in pH the amino group combines with H+ forming the NH3+ - group.
- HENCE, PROTEINS CAN BUFFER ACIDS AS WELL AS BASES
Which are the main proteins in the protein buffer system?
In red blood cells - HEMOGLOBIN
In plasma - ALBUMIN
Explain the carbonic acid - bicarbonate buffer system.
The carbonic acid - bicarbonate buffer system.
On H+ excess (low pH):
H+ + HCO3- => H2CO3
And, conversely, when pH rises:
H2CO3 => H+ + HCO3-
Explain the phosphate buffer system.
The phosphate buffer system.
On buffering a strong base:
H2PO4- + OH- => HPO42- + H2O
On buffering a strong acid :
HPO42- + H+ => H2PO4-
Explain different types of Acidosis.
Acidosis
- Arterial blood pH below 7.35
- Respiratory acidosis - for example in pulmonary insufficiens or ventilatory arrest
- Metabolic acidosis - for example diabetic ketoacidosis, renal insufficiens and certain specific intoxications (ASA, salmiak)
Explain different types of Alkalosis.
Alkalosis
- Arterial blood pH above 7.45
- Respiratory alkalosis - for example in hyperventilation
- Metabolic alkalosis - increased bicarbonate in serum. May be caused by vomiting and excessive intake of diuretic drugs
Explain Respiratory compensation.
Respiratory compensation
- On a decrease in pH, due to metabolic causes, hyperventilation may correct the acid-base imbalance
- Conversely, on an increase in pH, due to metabolic causes, hypoventilation will bring pH back toward the normal range.
Explain Metabolic compensation.
Metabolic compensation
- On a decrease in pH, due to respiratory distress, renal compensation - changes in secretion of H+ and reabsorption of HCO3- may correct the acid-base imbalance.
- Conversely, on an increase in pH, due to hyperventilation, renal compensation will bring pH back toward the normal range.
What is the function of the male sexual hormone (testosterone)?
Testosterone
- Derived from a steroid structure
- Many strange and important hormones are involved
- Midbrain (hypothalamus) → the pituitary gland → the testicles → testosterone is produced by the Leydig cells
- Testosterone acts on many target organs all over the body
What organs to the testosterone acts on?
- The muscles
- Fatty tissue
- The skeleton
- Psychological functions of the brain
- Erythropoesis
- Hair glands
- Male genitalia
Name different treatments of erectile dysfunction.
- Pubic ring, vacuum pump
- Viagra® Cialis® Levitra®
- Uprima®
- Bondil®
- Vitaros®
- Caverject®
- Sexual advising (sensuality training, treatment of ejaculatio praecox/retarda)