Urinary System Flashcards
Where is the kidney located in the body?
retroperitoneum (outside the rest of the abdominal organs)
What are the layers of connective tissue that cover the kidneys?
renal fascia, perirenal fat capsule, fibrous capsule
What are the main functions of the urinary system(3)?
filtering/excretion, regulation, hormone production
What are the two products that leave the kidney?
clean blood and waste (urine)
What is in waste excreted from kidneys?
salts, water, other waste
What is in the clean blood excreted from the kidneys?
cells, proteins, nutrients, ions, salts, water
What is the name of the blood vessels that take blood to and from the kidneys?
renal arteries and renal viens
What is the outer portion of the kidney called?
renal cortex
What is the inner portion (and the location of renal pyramids/columns) called?
renal medulla
What structures hold the collecting ducts?
renal pyramids
What is the space between the renal pyramids called?
renal column
What is the name of the tubes that deliver urine to the urinary bladder?
ureters
What is the structural/functional unit of the kidney?
nephron
Why are the capillaries of the glomerulus fenestrated?
small enough that cells can’t get through but filtrate can
What structure surrounds the glomerulus?
Bowmans capsule
Which layer of Bowmans contains podocytes?
visceral
What order does the filtrate flow through the tubules?
PCT, descending limb, loop of henle, ascending limb, DCT
Where does filtrate go after it leaves the distal convoluted tubule?
collecting ducts
Where do collecting ducts dump into?
renal pelvis
What is osmolarity?
amount of all molecules dissolved in 1L
What is the vasa recta?
capillaries surrounding the loop of henle
Where are the filtration slits?
between podocytes
What does a podocyte do?
its feet surround the glomerulus capillaries to allow filtrate to enter Bowmans capsule
Where do things that leave PCT go to?
peritubular capillaries
What is tubular reabsorption?
filtrate back to blood
What is tubular secretion?
blood into filtrate
What leaves the filtrate during tubular reabsorption?
water, nutrients, ions
What leaves the filtrate on the descending limb?
water
What leaves the filtrate on the ascending limb?
salt (Na+)
What are the main jobs of the DCT?
regulate blood pressure and flow rate into the nephron
Where do collecting ducts dump their waste?
renal pelvis
What is in the filtrate when it reaches the collecting ducts?
mostly water and waste
Where is the osmolarity the highest?
deep in the medulla
What creates the osmolarity gradient in the loop?
ascending limb pumping out salt
What causes the descending limb to pump out water?
osmolarity gradient
How is salt pumped out of ascending limb?
Na+/K+ ATPase pump
What is an aquaporin for?
allows for passive movement of water from high to low concentration
What is the counter current multiplier?
loop of Henle
What is the counter current exchanger?
vasa recta
What is the vasa recta?
large, slow moving, porous capillary
What does the vasa recta do?
uptake of salt and water from the interstitial fluid
Where are cortical nephrons found?
higher in the cortex
Where are juxtamedullary nephrons found?
they extend further down into the medulla
Why is the longer nephron helpful?
pulls more Na+ and water out of the filtrate
How does the collecting duct adjust urine concentration?
change the number of aquaporins
What hormone inhibits urine output?
antidiuretic hormone (ADH)
Does ADH add or remove aquaporins?
add
What causes more ADH to be released?
dehydration
What happens when the afferent arteriole vasocontricts?
decreased blood flow to glomerulus and decreased filtrate production
What happens when the afferent arteriole vasodilates?
increased blood flow to glomerulus and increased filtrate formation
What is glomerular hydrostatic pressure (GHP)?
pressure of blood pushing into Bowmans
What is capsular hydrostatic pressure (CHP)?
pushback from PCT due to filtrate buildup
What is colloid osmotic pressure (COP)?
suction of blood leaving on efferent arteriole
What is net filtration pressure (NFP)?
pressure that drives filtrate formation
What is the equation for NFP?
NFP= GHP-(COP+CHP)
What is the juxtaglomerular apparatus?
interface between afferent arteriole and DCT
What cells are in the wall of DCT?
macula densa
What do macula densa cells do?
measure Na+ and Cl- levels in filtrate
What are the cells in the wall of afferent arteriole?
granule cells
What do granule cells do?
measure blood pressure and release renin
What do macula densa cells release that constricts afferent arteriole?
ATP
What do macula densa cells release that dilate afferent arteriole?
nitric oxide
When do macula densa cells release ATP?
when you’re dehydrated
When do macula densa cells release nitric oxide?
when you’re hydrated