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BSAVA ECC > Urinary Module 1 > Flashcards

Urinary Module 1 Flashcards

1
Q

What if GFR?

A

This is the volume of fluid filtered from the renal glomerular capillaries in to the Bowmans capsule per unit in time

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2
Q

What tests can be used assess renal function?

A

Blood - urea, creatinine, SDMA
Urine - USG, sediment
Excretion tests to quantify GFR
Renal biopsy
Imaging
Culture and sens

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3
Q

What is creatinine to renal function

A

It is a late marker of renal function, need to see a reduction of 39-68% GFR to see changes, 75% changes relates to renal mass reduction
Released in muscle catabolism in a predictable way - mainly filtered through kidneys

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4
Q

What is urea to renal function

A

Made in the liver and produced by protein catabolism
It is decreased in animals with a negative energy balance/poor BCS, increased with high protein meal, GI haemorrhage increases
Not predictably released

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5
Q

AKI creatinine score

A

1-5, 3-5 will impact outcome

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6
Q

What is SDMA to renal function

A

released into circulation during protein degradation and is excreted by the kidneys
Almost exclusively renally excreted
Increased in about 40% loss of renal function - earlier than creatinine
dehydration, AKI, hypovolaemia and urinary obstruction will affect results

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7
Q

Imaging options for the kidneys/bladder

A
  • radiography: pneumocystogram
  • Urethrogram
  • Excretory Iv urography - renal pelvis
  • Ultrasound
  • CT/MRI/Scintigraphy
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8
Q

3 things to know about kidneys and neonates?

A
  • Renal function maturing till 8 weeks - hyposthenuria
  • Physiological proteinuria present for a few days due to MDA
  • Normoglycaemic glucosuria present
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9
Q

AKI pathophysiology

A
  1. Renal function impairment results from cell damage and or death most likely after diminished renal blood flow or O2 delivery
  2. Molecular changes activate destruction enzyme cascades and Na/K pump is influenced which results in changes electrolytes and cellular function - triggers inflammatory cascade (neutrophil activation and cytokine release activating vascular permeability)
  3. Cell edema contributes to tubular obstruction and formation of O2 free radicals and further toxic substance formation leading to progressive cell injury
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10
Q

7 Causes of AKI?

A
  1. Ischaemia
  2. Sepsis
  3. Toxins - ethylene glycol, lily tox, grape raisin, haemoglobinuria
  4. Drugs - NSAIDs, contrast agents, aminoglycosides
  5. Infections - pyelonephritis, lepto, babesia, lymes, leish
  6. Hypercalcaemia
  7. Hyperviscosity
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11
Q

What are clinical signs of renal impairment?

A
  • Uraemia
  • Isosthenuric urine
  • Hyperkalaemia
  • Hypertension
  • GI haem - abonormal bun/crea ratio
  • Increased phosphate
  • Acidosis
  • Changes to Na
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12
Q

Phases of AKI

A
  1. Initiation phase - initial insult resulting in tissue damage 0-36hrs
  2. Extension phase - damage from the insult extends - inflamm phase 48-72hrs
  3. Maintenance phase - stage where AKI is detected 7-21days
  4. Recovery phase - active repair 1-2 mths
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13
Q

Treatment of AKI

A
  1. Address/Treat cause: discontinue nephrotoxic drugs/treat infections/tx toxin
  2. Supportive care: Fluid therapy
  3. Uraemic signs tx: omeprazole, anti-emetic (maropitant, ondansetron, metaclop), pro-kinetics (metaclop/cisapride/low dose erythromycin)
  4. manage BP
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14
Q

How to manage oliguria

A
  1. Frusemide - acts diuretically on tubules - doesnt increase blood flow
  2. Mannitol - diuretic - can contribute to AKI at high doses
  3. Fenoldopam - renopreotective but not in AKI
  4. Diltiazem
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15
Q

How to manage hyperkalaemia

A
  1. Calcium gluconate - only works heart effects
  2. Glucose
  3. Glucose/insulin
  4. Terbutaline
  5. Bicarb
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16
Q

How do you establish IRIS CKD stage?

A
  • 2 fasted serum creatinine samples in a well hydrated patient
  • UPC 2-3 values
  • Arterial BP
17
Q

Management of CKD

A
  1. Fluid therapy
  2. Angiotensin converting enzyme therapy: Telimasartan
  3. Nutirtion
  4. Anaemai - darbo
18
Q

What are risk factors for pyelonephritis?

A
  • urolithiasis
  • ectopic ureter
  • urethral/ureteral blockage
  • urine retention
  • indwelling catheters
19
Q

Clinical signs and diagnosis of pyelonephritis

A

CS: abdo pain, uneven kidneys, dehydration, vomiting, stranguria/haematuria,
Dx: culture, u/s scan showing pylectasia

20
Q

Treatment abs for pyelonephritis?

A

Choose a renally excreted ab with gram -ve spectrum
- enroflox
- marboflox
- co-amox in stable and improving animals
- repeat urine culture 1-2 weeks after cessation of abs
- 2 weeks if simple, 4 weeks if complicated

21
Q

What is glomerulonephritis

A

most cases are caused by immune mediated complexes with the glomerulus that lead to proteinuria in the absence of UTI
- caused by increased urinary filtration with unaltered tubular resorption
- UPC consistently >2 in absence of active sediment

22
Q

Causes of nephrotic syndrome risk factors

A
  • steroid therapy
  • acute/chronic bacterial infections (endocarditis)
  • immune mediated disease
  • chronic inflam disease
23
Q

Clinical signs of nephrotic syndrome

A
  • Proteinuria
  • Hypoalbuminaemia - cavitary effusions
  • azotaemia
  • hyperlidaemia - upregulation of hepatic biosynthesis induced by hypoalbuminaemia or as compensation for low oncotic pressure
  • ultrasound: small kidneys with poor differentiation between cortex/medulla
24
Q

Treatment protocol for nephrotic disease

A
  1. Underlying disease
  2. ACE inhibitiors - enalpril, amlodopine - common side effect hyperkalaemia
  3. Manage hyperkalaemia - intestinal K+ binder, feeding low K+ diets, reduce ACE
  4. Diuretics
  5. Platelet/Thromboxane response - aspirin, clopidogrel, rivaroxaban
    fluid therapy
  6. Nutrition: phosphate restricted diet +/- feeding tube for increased albumin
25
Q

What are prognostic indicators for glomerulonephritis?

A
  • worse with canine amyloidosis
  • better for dogs than cats
  • worse with azotaemia
  • worse with borreliosis infection
  • treatment needs to reduce UPC by 1/3 is a good response but at lower UPC higher reductions needed
26
Q

Causes of ureteral obstruction

A
  • blood clots
  • neoplasia - trigone
  • ureteral strictures
  • stones (nearly all calcium oxalate)
27
Q

How to diagnosis an ureteral obstruction

A
  1. C/S: lethargy, anorexia, vomiting, ureamia, stranguria
  2. Abdominal palpation: small kidney/large kidney, pain
  3. Bloods: thrombocytopaenia, increased phosphate, pottasium, ca
  4. ultrasonography/radiography - concurrent uroliths: percutaneous antegrade pyelography, CT
28
Q

Management of ureteral obstruction

A

Medical mx - Fluids, osmotic diuretic, amytryptiline (relaxes smooth muscle), prazosin, glucagon (theoretical: relax of ureteral smooth muscle)
Surgical mx - nephrostomy tube, intermittent haemodialysis/renal replacement, stenting, lithotripsy, sub-bypass

29
Q

What is the stabilisation plan prior to urinary catheterisation with urinary blockage?

A
  1. IV access
  2. Pain relief
  3. Fluid therapy - hartmanns
  4. Hyperkalaemia mx
  5. Sedation/epidural
  6. Clip perineum and sterile prep
  7. Urinary catheterisation
30
Q

What are complications of ureteral surgery

A

Leakage - at nephrostomy site
Haemorrhage - during placement
system occlusion
kinking
UTIs

31
Q

What is the BPH rate in dogs over 5 and over 9

A

over 5 - 60%
over 9 - 95%

32
Q

What are other diseases that can be induced BPH

A

Prostatitis
Cysts
Abscesses

BSAVA ECC (31 decks)

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