Urinary/Excretory System Flashcards

1
Q

metabolism

A

reactions in a cell

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2
Q

secretion vs. excretion

A

secretion: releasing substance by exocytosis
excretion: eliminating metabolic wastes

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3
Q

Excretory organs maintain homeostasis by…

A
  • regulating body fluids
  • removing metabolic wastes from blood
  • controlling rate of RBC formation
  • regulating blood pressure
  • regulating absorption of calcium
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4
Q

water is a by-product of…

A

dehydration synthesis & respiration

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5
Q

CO2 is a by-product of…

A

cellular respiration

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6
Q

salts are a by-product of…

A

neutralization

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7
Q

urea is a by-product of…

A

amino acid metabolism

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8
Q

deamination

A

removing amino group from amino acid & converting it into ammonia

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9
Q

3 ways the liver helps with homeostasis

A
  • removes bilirubin
  • produces urea
  • detoxifies blood
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10
Q

How do drugs/alcohol affect the liver?

A

They kill liver cells, so the liver struggles to detoxify substances

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11
Q

the body system our skin belongs to

A

integumentary system

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12
Q

urine has the same components as what?

A

sweat (made of water, salts, and urea… aka metabolic wastes)

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13
Q

4 main structures of urinary system

A

kidneys, ureters, urinary bladder, urethra

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14
Q

urinary system

A

organs that produce, store, & rid the body of urine

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15
Q

functions of urinary system

A

excretion, maintenance of water-salt balance, maintenance of acid-base/pH balance, secretion of hormones & enzymes

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16
Q

excretion

A
  • removal of metabolic wastes (NOT defection!)

- ex. ammonia, urea, uric acid

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17
Q

ammonia

A

formed from breakdown of amino groups in a.a.’s… very toxic

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18
Q

urea

A

liver converts ammonia into less toxic urea

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19
Q

uric acid

A
  • formed from breakdown of nucleotides

- too much uric acid causes gout

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20
Q

gout

A
  • formed by excess of uric acid

- painful arthritis-like condition that affects joints, esp. big toe

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21
Q

maintenance of water-salt balance

A
  • kidneys regulate NA+, K+, HCO3, and Ca2

- balance of ions affects osmotic concentration of blood

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22
Q

maintenance of acid-base (pH) balance

A

keeps blood pH at 7.4 by excreting H+ and reabsorbing HCO3

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23
Q

renin

A

affects release of aldosterone -> regulates blood pressure

24
Q

erythropoietin (EPO)

A

tells bone marrow to produce RBC

25
calcitrol
helps intestine absorb calcium from food
26
kidneys
- primary organs of urine production | - on either side of spine below diaphragm & anterior to deep back muscle
27
hilium
- part of the kidney | - renal artery enters & renal vein leaves
28
ureters
- small muscular tubes that transport urine from kidney to bladder - peristalsis moves urine
29
urinary bladder
- muscular organ that expands as urine enters | - holds up to 600ml of urine
30
urethra
- extends from bladder to external opening - 4cm in females, 20cm in males - shorter length in females makes them more prone to UTI - in males, urethra is surrounded by prostate gland & also carries sperm
31
What problem can arise with the prostate gland?
As males age, the prostate gland can enlarge and restrict urine flow
32
3 major regions of kidney
- renal cortex: outer layer - renal medulla: inner layer, consists of cone-shaped renal pyramids - renal pelvis: central cavity leading to ureter
33
nephron
microscopic units of kidneys that produce urine... one million per kidney
34
Blood supply pathway
renal artery -> kidneys -> afferent arteriole -> glomerulus -> efferent arteriole -> peritubular capillary -> venule -> renal vein
35
glomerulus
capillary knot inside nephron
36
path of filtrate
nephron -> collecting ducts -> renal pelvis -> ureter
37
characteristics of urine
- 95% water | - 5% solutes
38
solutes include
- ions: H, K, Na, Ca, Cl, Mg - ammonia, sulphates, phosphates - urea - creantinine - uric acid (organic compound from purine breakdown) - others: carbs, enzymes, fatty acids, hormones, pigments & mucins
39
colour of urine
- old decomposed RBC -> bilirubin -> urobilin = yellow - urinate less = less yellow (diluted urobilin) - if urine stored for a while (ie. overnight) = darker yellow
40
changes to smell
- diabetics have a sugary smell to their urine | - asparagus can also cause a strong odor
41
Process of urine formation
- waste-filled blood enters kidneys - glomular or pressure filtration occurs - tubular or selective reabsorption - loop of henl - tubular secretion
42
Waste-filled blood enters kidneys
- afferent arterioles enter Bowman's capsule & form a ball of capillaries called glomerulus - efferent arteriole is smaller diameter than the arteriole so blood pressure builds up in glomerulus - blood pressure forces substances from blood into Bowman's capsule
43
Glomular or pressure filtration
- material forced out of blood = filtrate - has h2o, a.a.'s, glucose, salts, & urea - larger particles (blood cells, proteins, & fats) can't leave capillaries, so they stay in blood & leave via efferent arteriole - efferent arteriole branches into peritubular capillaries which form a mesh around nephron - filtrate moves into proximal convoluted tubule
44
Tubular or selective reabsorption
- in proximal convoluted tubule where some filtrate returns to bloodstream - lined with villi to enhance absorption - active transport moves glucose, a.a's, and Na back into blood - Cl follows passively because it's attracted to Na - with salt leaving (NaCl), h2o follows by osmosis - if amount of substance exceeds number of carrier proteins, not all can be reabsorbed so it ends up in urine
45
Loop of Henle
its main job is to regulate water concentration
46
Tubular secretion (excretion)
- 2nd place where substances leave blood & enter nephron - distal convoluted tubule not permeable to H20, so H20 enters capillaries, not nephron - excess H & K ions, drugs, uric acid, products from the breakdown of hemoglobin, histamines, etc. move by active transport from blood to nephron - distal tubules drain into collective duct where more H20 diffuses back into surrounding tissue makes urine more concentrated than blood - fine-tuning of H20 concentration occurs in distal convoluted tubule & collecting tubule
47
osmolarity
- number of particles per volume of fluid | - maintaining osmolarity in tissues involves h20 regulation
48
H20 regulation occurs through...
- direct control using ADH | - indirectly through aldosterone
49
Anti-diuretic hormone (ADH)
- control of h20 excreted relies on ADH (aka vasopressin) - diuresis means "water-loss", so ADH mean "anti-water-loss hormone" - ADH is made in hypothalamus & stored in posterior pituitary gland - makes you thirsty -> you'll drink more
50
Steps of ADH secretion
h20 level drops -> osmolarity increases -> osmoreceptors in hypothalamus direct ADH to be released from pituitary -> ADH binds to receptors of cell on collecting tubule in nephron -> triggers chain of events that lead to insertion of aquaporin channels in collecting duct & distal tubule -> membrane becomes more permeable to water -> water flows out of tube into capillaries to be reclaimed by body -> H20 builds up in body -> osmoregularity back to normal -> shuts down hypothalamus... until the cycle begins again
51
If blood is too dilute (ie. after large intake of H20)...
- ADH secretion is inhibited - aquaporin channels removed by endocytosis - h20 can't leave nephron -> large volume of urine
52
How to alcohol & caffeine affect urination?
- inhibit ADH | - urine volume remains large & dehydration can result
53
Aldosterone
- low Na concentration in blood sensed by kidney - through chain of complex chemical signals, kidney sends message to adrenal cortex which releases aldosterone - aldosterone causes nephrons to reabsorb more Na and water back into blood and to excrete more K in urine - when blood Na concentration returns to normal, aldosterone release is stopped
54
acid-base balance
- pH maintained by controlling H levels - only urinary system can eliminate excess H a) HCO3 from nephron moves to capillaries -> resupplies the blood with buffers b) H removed from blood & excreted
55
loop of henle - water control
- descending limb permeable to H20, so it diffuses into surrounding fluids - filtrate becomes more concentrated as it moves down DL - ascending limb impermeable to H20, but pumps out Na and Cl by active transport - due to that ^, as filtrate moves along AL, it comes less concentrated - at top of AL, there's less filtrate, but it's almost as concentrated as it was at the start of DL - in tissue surrounding loop of Henle, salt gradient is established, increasing concentration from top to bottom of loop & establishing countercurrent multiplying effect - fluid at top of collecting duct has salt concentration about equal to beginning of the loop of Henle - as fluid descends collecting duct, it's exposed to the surrounding salt gradient established by loop of Henle - without ADH, collecting duct is impermeable to H20. 2 outcomes are possible: a) if H20 is needed, ADH simulates opening of aquaporins, allowing H20 to move out of duct and into surrounding tissues b) if h20 not needed by body, no ADH & duct allows h20 to drain out of body