Urinary Flashcards
Does the presence of bacteria always lead to clinical signs?
no
subliclinical bacteriuria
a true urinary tract infection (and not a subclinical bacteriuria) is called
sporadic bacterial cystitis
How do we differentiate subclinical bacteriuria with sporadic bacterial cystitis?
bacteriuria
and
LUT clinical signs:
- pollakiuria
- stranguria
- haematuria
- dysuria
A patient with sporadic bacterial cystitis usually have how many episodes per year?
<3
does sporadic bacterial cystitis affect dogs or cats more commonly?
common in dogs
rare in cats
patients are otherwise healthy :)
What are host risk factors for UTI
- obesity
- female
- inability to void (neurological)
- urinary sphincter mechanism incompetence
- increasing age
- anatomical abnormalities of the urinary tract
- urolithiasis
What are the hosts defence mechanisms against UTI
- normal micturition
- anatomy of the UT
- mucosal defense (ie exfoliation of cells, GAG, exfoliation of cells)
- antimicrobial properties of urine (low or high ph, peptides, Lmw CHO)
- systemic immunity
what is recurrent bacterial cystitis?
> 3 times/ year
2 times/ year
will show clinical signs
Does urolithiasis predispose to bacterial infections?
yes
risk factors for bacterial UTI
- recent use of Ab
- catheterisation
- immunosuppression
- conditions resulting in dilute urine (DM, CKD)
- secondary to inflammation or trauma to UT
bacterial uropathogens are usually
commensals that infect via ascending infection
usually a single causative agent (90%)
What are the 4 most common uropathogens in SM?
- proteus
- E.Coli
- enterococcus
- CN staphylococcus
What are the most common uropathogens in LA?
same as SA
and Corynebacterium (can result in pyelonephritis)
How do bacteria persist in UTI?
- replicate within tissues
- Biofilm
How do you start your investigation on a UTI
- consider cx
- urinalysis
- definitive dx and tx based on quantitative urine culture
What is the most appropriate sample collection for urine for assessing UTI
- cystocentesis (gold standard)
- alternative option: aseptic catheterisation
can also perform cultures on:
- bladder biopsy
- cystolith
What is the least ideal sample collection for urine for assessing UTI
free catch
(sometimes this is the only method available, may need to follow up with a cystocentesis, consider difficulties in interpretation)
What does urinalysis not tell us about that we need to know for treatment
which antibiotic to use
What information is provided on a urinalysis
- SG: is urine concentrated?
- dipstick: proteinuria? hematuria? glucosuria?
- sediment
Does sporadic bacterial cystitis require further diagnostic investigation
no
Does recurrent bacterial cystitis require further diagnostic investigation
yes
What are the 1st line antimicrobials used for tx of sporadic bacterial cystitis?
- Amoxicillin
- TMPS
- (Amoxi-clav reasonable)
What does the sediment tell us?
- hematuria?
- pyuria (wbc)?
- crystalluria?
If a young cat has a suspected UTI should you do Culture?
YES, as it is rare for them to have bacterial UTI
if a male dog has recurrent UTI what antibiotic may you choose?
antibiotics that can penetrate the prostate
ie TMPS or fluoroquinolone
How do we monitor for resolution of a case of sporadic bacterial cystitis?
- resolution of clinical signs within 48H
(no need to repeat UA, or Urine culture)
If following treatment of a sporadic bacterial cystitis signs not resolving what do you do?
- switch to antibiotic based on C & S
how long are antibiotics for sporadic bacterial cystitis prescribed for?
3-5 days
If treatment sporadic bacterial cystitis fails- what may be the causes?
- infection not the cause of the clinical signs?
- inadequate delivery of Ab (poor owner compliance, animal factors, inappropriate drug so poor penetration)
- antibiotic resistance? (intrinsic or acquired)
- undiagnosed predisposing factors (urolithiasis)
Should you treat recurrent bacterial cystitis with longer course treatment?
No
still do 3-5 days
Unless kidney or prostate involvement (7- 14d)
If you have a patient with recurrent bacterial cystitis how would you investigate?
Will depend on other clinicals signs
- bloods
- imaging
- endocrinology testing
- urine C& S
urine output goes down if
filtration is not occurring
urine output goes up if
reabsorption is not occurring
problem with urinary filtration
urine output decreases
problem with absorption of filtrate
urine output increases
99% of urine filtrate is
reabsorbed
Storage of urine is controlled by the
SNS (hypogastric)
allows bladder to relax and fill
the PNS Pelvic nerve allows the bladder to
void via contraction bladder wall
Which nerves control the voluntary control of the urethra
pudendal nerves
polyuria*
greater than normal urine output
anuria*
no urine output
oliguria*
less than normal urine output
what is the normal urine output of dog and cat
15-45ml/kg/day
pollakiuria*
- frequent passage of urine (small amounts)
- total daily amount of urine not increased
urinary incontinence
involuntary passage of urine
nocturia
urination at night
periuria
innappropriate urination (wrong time wrong place)
dysuria
difficult painful urination
stranguria
slow and painful. used interchangeably with dysuria
Is it easier to feel the kidneys in a dog or a cat?
the cat
very difficult to feel in dog, but can still try!
Which kidney is more difficult to feel in the cat?
the right one
tucked under ribs
is blood work useful in investigating LUT disease
No
more useful for Upper urinary tract
during a cystotomy where do you place the stay suture to hold in place and where do you cut the bladder?
- place stay suture on apex
- cut the median ligament
- cut ventral midline
Why would you do a cystotomy?
- remove cystic and urethral calculi
- to do an incisional/ excisional biopsy
- treat ectopic ureters
urolithiasis can affect which parts of the UT?
- Upper
- Lower
How would you approach a urinary tract obstruction?
- history
- stabilise (bloods, ECG, fluids)
- urinary diversion
- imaging (localise uroliths/ obstruction)
- remove uroliths and send for analysis
where may you make the stoma for a permanent urethrostomy in the male dog?
scrotal
where may you place a permanent urethrostomy in the male cat?
perineal
following a cystotomy, when closing up the incision which layer must you include?
the submucosa
If you have a urolith in the urethra how can you remove them?
- retropropulse them back into bladder
- cystotomy
If during a cystectomy you need to remove part of the trigone, what will need to be done next?
- ureteral re-implantation (referral)
what is more risky- urethrotomy or a cystotomy?
urethrotomy!!
increased risk of rupture
increased risk of hemmorhage
When do you consider doing a urethrotomy
ONLY when a cystotomy is not possible
what are the complications of cystotomy
- urolith recurrence
(or failure to completely remove) - cystotomy breakdown–> uroabdomen
- hematuria/ blood clot
- dysuria
urethrotomy will vary according to which part of the ureters are affected in the MALE dog- which parts are these?
- glans penis
- prescrotal
- (perineal) less common
What surgery is this? in which part?
Urethrotomy
prescrotal
the preferred site for urethrostomy in the dog
scrotal
the preferred site for urethrostomy in the cat
perineal
urethrostomy you make an opening in the urethra and suture the sides to
the skin
Permanent urethrostomy in the male cat usually involves amputation of the
penis
Permanent urethrostomy of the female patients involves which sites
-transpelvic, subpubic,prepubic
VERY COMPLICATED procedure!
What suture pattern do you make on the bladder when placing a cystostomy tube?
purse string, the catheter will go inside it
What are the treatments for USMI?
bladder neck relocation
bladder neck lengthening
increasing urethral resistance (prosthetic sphincter, bulking agents)
How do you treat intramural ectopic ureters
- side to side neo-uterocystotomy
- uteroneonephrectomy
During a cystotomy you make an incision on the bladder where
ventrally
what are the risks associated with pre-pelvic urethrostomy
increased risk of infection as urethra is shorter
urinary incontinence
a cystostomy tube is secured externally with which suture?
Roman sandle
Which muscles do you cut in a permanent urethrostomy in cat
- retractor muscle
- ventral penile ligament
- ischiocavernosus muscles
increases mobility of the urethra
What is the reference landmark for perineal urethrostomy in cats
bulbourethral gland
If performing a scrotal permanent urethrostomy in a dog- will you need to castrate?
yes
Should you take rectal temperature and clean following a permanent urethrostomy?
No
How do you surgically correct extramural ureters?
ureteral re-implantation
Functional urethral obstruction is dyssynergia between
the detrusor muscle contraction and urethral relaxation
no anatomic reason for obstruction
Diagnosis of functional urethral obstruction is a diagnosis of
exclusion
What is the most common cause of UT obstruction
urethral
What is the most common cause of urethral obstruction in the dog?
urolithiasis
What is the most common cause of urethral obstruction in the cat?
urethral spasm
Name some extra-mural causes of urethral obstruction
- perineal rupture
- trauma (ie penile)
- bladder mass
- prostate disease
- pelvic mass
Name some intra-urethral causes of obstruction
- calculi
- inflammation (proliferative urethritis)
- tumours
lesions cranial to the sacral segments may lead to firm bladder or a flaccid bladder?
firm bladder (UMN)
Where is the most common site for urinary obstruction in the male dog?
1) os penis
2) just after the ischium
Where is the most common site for urinary obstruction in the male cat?
os penis
If you suspect a urinary obstruction, and pass a catheter and find no blockage does that exclude obstruction?
NO
- may have:
functional obstruction
partial obstruction
clinical signs associated to urinary tract obstruction will vary according to
- partial or complete obstruction
- acute/ chronic
- underlying cause
urinary obstruction can be mistaken for
- constipation
- other disease if animal collapsed
Is azotemia due to severe urethral obstruction reversible ?
- yes
What are the effects of urinary obstruction on the bladder?
- bladder distention
- ischemia
- oedema
- hemmorhage
- mucosal sloughing
- ureteral reflux
urinary obstruction will lead to what systemic effects?
- hypotension
- hypovolaemia
- biochemical changes
What are the biochemical changes seen. in urinary obstruction? Are they reversible?
- azotemia
- hyperglycemia (cats)
- hyperphosphatemia
- hypocalcemia
- hyperkalaemia
YES REVERSIBLE
In a urinary obstruction what happens to blood potassium?
hyperkalaemia
What are the effects of hyperkalaemia on the CVRS system?
- bradycardia
- ventricular arrhythmmias
- prolonged PR interval
Why is urinary obstruction an emergency?
Indwelling urinary catheters with closed urinary system post obstruction - should we use them?
only when necessary- sometimes make urethral spasms worse
When should antibiotics be given when using indwelling catheters?
give antibiotics only after removal
What is the preferred method for managing urethral calculi in male dogs and cats
retrograde hydropropulsion
How do you manage an emergency urinary obstruction?
1) Take bloods
2) correct hyperkalaemia
3) give fluids
4) give calcium
5) cystocentesis
6) sedate and place a urinary catheter
7) take samples
8) bladder lavage
After unblocking a patient prepare for
- hypokalaemia
- diuresis
How are uroliths formed?
supersaturation—> nucleation
Can you have crystals without uroliths and uroliths without crystals?
YES
How can crystals dissolve?
decrease solute concentration
Are cystoliths palapable?
generally not
urethroliths can lead to what type of obstruction?
post renal azotemia (obstruction)
What clinical signs are seen with uteroliths and nephroliths?
usually asymptomatic
urethroliths give what clinical signs?
- abdominal discomfort
- poor or no urine stream
- enlarged painful bladder
- may be palpable
what type of contrast radiography do we use to visualise the urethra?
retrograde
what type of contrast radiography do we use to visualise the nephroliths and uteroliths?
excretory urogram
what type of contrast radiography do we use to visualise the bladder?
double contrast
What is renal colic?
pain that occurs when stone moves down the ureter
What is this?
US of cystolith
note the acoustic shadows
What factors help determine a stone type?
- SIGNALMENT (70%)
- urine ph
- radioopaque Vs radioluscent
- history of a particular stone type
- disease associations
UTI are associated with which stone type?
struvite
urolith analysis- quantitative or qualitative
quantitative
nephrolith tx
- if asymptomatic leave alone
- surgical removal
- lithrotripsy
uterolith treatment
referral (lithotripsy for dogs)
What urolith is not amenable to dietary dissolution ?
Calcium oxalate
treatment for cystolith
- medical dissolution
- hydropropulsion
- surgery (cystotomy)
treatment for urethrolith
- retrograde flush
- surgery (avoid if possible)
When can we consider medical management for uroliths?
- no obstruction
- no contraindications to dietary therapy
- stone amenable to dissolution (strucite, urate, cysteine)
What causes struvite crystals in dogs?
bacteria (proteus..) with urease that convert urea into ammonium and bicarbonate
In cats struvite crystals are …
sterile
treatment of struvite crystals
acidifying diets
The use of acidifying diets for … crystals have predisposed the formation of …. crystals
- struvite
- calcium oxalate