LOCO LA Flashcards
Supporting limb laminitis is due to ….
poor peripheral perfusion
Is supporting limb laminitis also due to mechanical overload?
NO
Is equine laminitis a disease?
No it is a syndrome
What is the most common cause of equine laminitis?
endocrinopathic- hyperinsulinemia
Does glucose toxicity and deprivation contribute to endocrinopathic laminitis?
No it does not.
What are the 3 causes of endocrinopathic laminitis?
1- PPID
2- GC
3- Equine Metabolic Syndrome
Can prednisolone or other corticosteroids initiate laminitis in a horse?
No, unless the horse is predisposed to hyperinsulinemia. Prednisolone can increase the chance of recurrence only.
What causes the Pars Intermedia in the horse to secrete more cortisol and CLIP hormones in laminitis?
loss of DA inhibition
What are the mechanisms that lead to loss of hemidesmosomes in the equine foot leading to inflammatory laminitis?
1- Inflammation (cytokine release, leucocyte adhesion, endothelial activation)
2- Hypoxia
Lead to structural damage
Medical treatment for PPID
Pergolide
Medical management of sepsis induced laminitis in horses
- anti-endotoxins
- digital cryotherapy
- treat underlying cause
Prevention for EMS laminitis in horses
- Reduce NSC consumption
- exercise
- weight loss
What do all horse laminitis cases have?
Bounding pulses
Is equine laminitis an emergency?
Yes
Prognosis of equine laminitis will depend on
- previous history
- severity of coronary band depression
- degree of pedal bone rotation
Can OA be cured?
NO
Degenerative joint disease is a … process
inflammatory
In Degenerative joint disease which structures produce inflammatory cytokines leading to matrix breakdown?
All of them
In Degenerative joint disease (DJD), what increases and decreases (water, collagen, proteoglycans)
- water increases
- collagen decreases
- proteoglycans decrease
is synovitis and joint distention painful?
Yes
Where are the pain receptors located in a joint?
- The subchondral bone and the joint capsule
- NO receptors on the articular cartilage
Does the articular cartilage have pain receptors?
No
What are the goals treatment in DJD?
- stop inflammation
- restore joint function
- reduce pain
- chondroprotection (disease modifying drugs)
What questions when hx taking would you ask when assessing a lame horse?
- How many limbs? 1, 2, multiple?
- other horses affected?
- history of trauma
- behavioural changes before?
- onset?
- duration?
what would you look for on a PE when assessing a lame horse?
- which limb is lame?
- is it lameness or laminitis?
- score lameness on 0-10
- where in limb? dx analgesia (intra-articular)
- joint swelling? fibrous thickening? effusions? crepitus?
- palpation and manipulation (ie. ROM)
- muscle atrophy
what diagnostis tools do you have for assessing horse lameness?
- local analgesia (peripheral nerve blocks vs intra-articular analgesia)
- diagnostic imaging (X-rays, US, CT)
- synovial fluid analysis (usually performed in infection is suspected)
What is the mainstay drug of choice for horses with OA?
NSAIDs
What features may you see on OA bone?
- new bone
- soft tissue swelling
- dystrophic mineralisation
- effusion
What NSAID can be used during pregnancy?
None
When can you not use an NSAID in a horse?
- pregnancy
- liver disease
- if using corticosteroid
- if using another NSAID
- in a bleeding disorder
- unaddressed dehydration
What farm animals have licensed NSAIDs?
- Pigs
- Cows
- Horses
What conditions in the horse have licensed NSAIDs for them?
- colic
- musculoskeletal disease
65% of Antibiotic use on sheep farms is due to what disease?
lameness
Unlike cattle, most causes of sheep lameness are….?
contagious
This shows that sheep wall horn length varies with the time of year- isnt this great?
yes
What is the most common cause of lameness in sheep?
Scald
What is this?
Scald
inflammation of the interdigital skin
How do you treat scald?
- oxytetracyclin
- control footrot as footrot predisposes to scald (same bacteria)
What is this? What other disease does it look like?
Footrot
it resembles scald-
What distinguishes footrot from scald?
Like scald it has inflammation of the interdigital space, white grey scum and a smell.
But it has under-running of the hoof horn
Should you trim footrot in sheep?
NO!!!!!!!!
give oxytetracyclin, penicillin or macrolides in refrac cases
What is the causative agent of footrot in sheep?
D. nodosus
If footrot treatment is delayed that could lead to …
toe granuloma
How does D. Nodosus cause footrot and underunning of hoof horn?
digestive proteases
D. nodusus co-infects the sheep foot with which other bacteria?
Fusobacterium Necrophorum
Regular foot paring, regular foot bathing and regular buying in of new sheep has been associated to increased levels of…
lameness
What reduces sheep lameness incidence on a farm?
- closed flock
- isolating affected sheep
- quarantining new stock
- treating affected sheep in less than 3 days
What is the five point plan for the prevention of footrot?
1- DO NOT TRIM
2- CULL (heritability- reservoir for disease)
3- Quarantine
4- Vax
5- environmental factors ( unidirectional flow in footbaths, dry bedding, cleaning shears after use)
Why is footbathing bad for sheep?
Its bad if it is done poorly - can spread disease easily
What footbathing options do we have for sheep?
3% formalin
10% zinc sulphate
Should you footbathe a lame sheep?
NO!!!!
What’s bad about formalin footbaths?
- carcinogenic
- painful
- inactivated by organic matter
What is this?
CODD
3rd most common cause of sheep lameness
What causes CODD?
Treponeme
How do you treat CODD
do not trim!
systemic Amoxicillin Ab
topical oxycyclin
What is this?
Shelly hoof
separation of sole horn with wall horn leads to pockets. These pockets can fill with mud and debris which may make the animal lame.
What is this?
CODD
How do you treat Shelly hoof?
- Pare off the pocket
What predisposes to Shelly hoof?
- genetics
- nutrition
- underfoot conditions
What is this?
Foot abscess
bacteria penetrate the white line- then pus bursts out of coronary band!!
How do you treat a foot abscess?
Pare off foot to RELEASE PUS!!
systemic antibiotics
What is this? What causes this?
Toe granuloma
red polyp made of granulation tissue.
caused by exposure of the corium
Do you need to treat this or can you just let it heal?
It will not heal on its own!!!
remove loose horn
cut neck of the polp
apply pressure bandage
change dressings weekly
plus systemic antibiotics
What is this?
Septic pedal arthritis
Where is the infection? How did this infection occur?
the distal interphalangeal joint
- infection may have spread from foot or directly infection via a sharp object
How do you treat this?
arthrodesis or amputation
What is this?
strawberry foot
What causes this?
Co infection with ORF and D.Congolensis
What are the 3 causes joint ill in sheep?
- S. Dysgalactia (neonatal bacteriemia)
- E. Rhusiopathia (wet conditions)
-tick bite pyemia
How can you prevent joint ill in sheep?
Navel dip
wear gloves at lambing
ensure housing is clean
Should we be trimming goats feet? why?
Yes
they have different management to sheep
Why do we tend to get laminitis in goats?
high concentrate diets
What bacterial agent has been associated to goat CODD like infections?
treponemes
Goat feet infections are caused by what two factors?
laminitis
Treponemes
Limb movement can be described is composed of 2 things
1- travel
2- action
Define travel (relating to limb movement)
travel is the flight of a hoof in relation to the other limbs.
It is a 2 peaked curve
What are the phases of stride in a horse?
landing- loading-stance-
breakdown- swing/ flights
Define action (relating to limb movement)
overall gait characteristics
varies between breeds
ie TB are designed for flat racing
When a lame horse is trotting, will the sound limb or lame limb make more noise?
“The sound limb makes more sound”
Which gait is best to analyse lameness?
the trot (2 beat)
Which gaits do not detect subtle lameness?
walk (4 beat)
canter (3 beat)
why do we want to identify the source of lameness in a limb when doing a PE?
To allow for targeted diagnostic imaging
In FL lameness, the head will drop on which limb?
the sound limb
Inertial sensors are placed in which 3 areas?
the poll
tuber sacrale
tuber coxae
If the horse is left FL lame, which FL will have increased movement on inertial sensors?
The Right FL will have increased movement > Left FL
Which side will have an increased pelvic hike?
the lame side
“Fetlock drop” can be seen on the lame side or the sound side?
The fetlock drop is more pronounced on the sound side except for when there is suspensory ligament/ tendon damage
Inertial sensors of the HL- will the sound or lame limb have increased excursion?
the lame side will have increased excursion