Urea cycle Flashcards
Where does the urea cycle take place?
The liver
What is the start of the urea cycle? A combination of what (2) to make what?
A combination of ornithine and carbamoyl phosphate to make citrulline
What are the 2 outcomes of the urea cycle?
Urea and ornithine
Where do the 2 N’s come from in urea?
1 from carbamoyl phosphate
1 from aspartate
Where does carbamoyl phosphate primarily obtain its N?
Glutamine
_____________is an amino acid that serves as a significant carrier of ammonia in the body.
glutamine
Where does carbamoyl phosphate come from?
C and O come from _____________
P comes from ____________
P is lost when combined with ornithine to make __________________
N comes from _______________
Bicarbonate ion (from the CO2 produced in the CAC)
ATP
Citrulline
Ammonium ion from the deamination of AAs
Where is ammonia made? How is it excreted?
In the liver. Transported to the kidneys and excreted In the urine.
Which 2 pieces is argininosuccinate cleaved into?
arginine and fumarate
What molecule is combined with citrulline in a reaction driven by ATP and pyrophosphate?
Aspartate
In the last step of the urea cycle, hydrolysis of ___________ gives ___________ and regenerates the reactant in step 1, ornithine.
arginine, urea
Which 5 enzymes are used in the urea cycle. In order, starting with
1.) carbamoyl phosphate synthase
1.) carbamoyl phosphate synthase
2.) Ornithine transcarbamoylase
3.) Argininosuccinate synthase
4.) Argininosuccinase
5.) Arginase
What does Ordinary Careless Crappers Are Also Furious About public Urination stand for?
1.) Ornithine
2.) Carbamoyl phosphate
3.) Citruline
4.) Aspartate
5.) Argininosuccinate
6.) Fumerate
7.) Arginine
8.) Urea
