upregulation

Question 1

central sensitization or wind up phenomenon leads to

In regards to treatment of pain effectiveness

Answer 1

nonresponsive or chronic intractable pain

Question 2

central sensitization or wind up phenomenon leads to changes in nervous system
2

Answer 2

hyperalgesia

allodynia

Question 3

when spinal neurons are subjected to repeated or high intensity nociception they become

Answer 3

increasingly excitable even after stimulus is removed

Question 4

define

chronic maladaptive pain\neuropathic pain/wind up pain

Answer 4

hypersensitivity resulting from abnormal processing response in the CNS

Question 5

injury or inflammation alters the chemical environment surrounding the nociceptor how?

Answer 5

sensitization increased intensity of noxious stimulation

• axonal sprouting and neuroma formation
• upregulation of Na Channels
• down regulation of K channels

Question 6

increased nociceptor input leads to ______
in regards to chronic pain leads to physiological changes
Name 3

Answer 6

maladaptive changes ( neuroplascity) in dorsal horn and cns
-phenotype switch
GI to GS
-propeceptive Ab fibers transmit pain instead of normal signal