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Pharma 5 > 5.3 endogenous opioids and receptors > Flashcards

5.3 endogenous opioids and receptors Flashcards

1
Q

preproopiomelancortin synthesized to

ACTH
B-endorphin
met-enkephalin
leu-enkephalin
Dynorphins A&B
A

ACTH
B-endorphin

anterior pituitary/immune

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2
Q

Preproenkephalin synthesized to

ACTH
B-endorphin
met-enkephalin
leu-enkephalin
Dynorphins A&B
A

met-enkephalin
leu-enkephalin

ens cns

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3
Q

preprodynorphin synthesized to

where

ACTH
B-endorphin
met-enkephalin
leu-enkephalin
Dynorphins A&B
A

Dynorphins A&B
leu-enkephalin

ENS CNS

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4
Q

mu, delta, and kappa receptors all cause

A

analgesia

  • spinal
  • supraspinal
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5
Q

Mu receptor causes

4

A

respiratory depression
inhibit GI motility
euphoria
miosis

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6
Q

K receptors

4

A

inhibit GI motility
psychotomimetic-(psychosis, delusions ,delirium, psychotic alteration of behavior and personality)
dysphoria
miosis

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7
Q

B-endorphin
receptor
main physiologic effect

A

mu delta

analgesia

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8
Q

met-enkephalin
leu-enkephalin
receptor
main physiologic effect

A

mu delta

analgesia

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9
Q

Dynorphins A&B
receptor
main physiologic effect

A

K

analgesia

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10
Q

ACTH
receptor
main physiologic effect

A

MC2R

adrenal stimulation

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11
Q

Mu 2 effects

4 Unfavorable

A

bradycardia
respiratory depression
constipation-inhibit GI motility
miosis

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12
Q

B endorphin how many AA

A

31

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13
Q

Dynorphin A&B how many AA

A

13

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14
Q

Enkephalins how many AA

A

5

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15
Q

post transcriptional modification is ?

A

alternate splicing of receptor mRNA to make subtypes

mu 1,2,3

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16
Q

post translational modification is

A

the way we make our endogenous opioids from big precursor proteins

each precursor has separate gene and separate mrna

17
Q

MAPK cascade is activated leading to

A

gene expression and neuroplasticity which leads to addiction, tolerance, and opioid induced hyperalgesia

18
Q

opioids cause what in the cerebrum

A

sedation

19
Q

opioids cause what in the supraspinal (central)

A

truncal rigidity

20
Q

Respiratory depression is a result of activation of mu receptors where

A

brain stem respiratory center

21
Q

Hypoxic drive is ____by opioids

A

decreased

22
Q

Apneic threshold is _____by opioids

A

increased

higher CO2 level required to take a breath

Pharma 5 (9 decks)

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