drug unique properties Flashcards
Which two drugs cause histamine release
morphine and meperidine
This drug has a long half life and is used to treat opioid addicts by removing them from the places and people that inspire them to use
methadone
This drug can be subdermal implanted lasting 6 months
buprenorphine
These two drugs have a lower abuse potential because of being a mixed agonist-antagonist
Resp depression?
buprenorphine butorphanol
yes
this drug will cause resp depression, sedation, drowsiness, dysphoria, psychotomimetic effects, but has lower abuse potential
IV only
butorphanol
This drug can revers opioid induced urinary retention and reverse fentanyl induced resp depression while maintaining some pain relief, but might make the patient crazy
nalbuphine
This drug is long acting mu kappa delta antagonist,
can be taken orally, used to treat delayed resp depression, used to treat opioid addiction.
naltrexone
can cause severe withdrawals
This drug is quintenary amine and is used to treat OIC
methylnaltrexone
this drug is a GI specific opioid receptor antagonist
broken down in intestine, treats OIC
doesn’t cross BBB so doesn’t decrease pain relief
alvimpoan entereg
this is the least lipophilic opioid
morphine
structurally similar to atropine
meperidine
this drug is metabolized into an excitatory metabolite that would be bad for a patient hepatic issues or on mao inhibitor
can cause serotonin syndrome(hypothermia, delirium, convulsion
meperidine
10% unionized in plasma
fentanyl
highly protein bound opioid, toxic for elderly
fentanyl
Renal failure patients would want to avoid what two opioid drugs
morphine meperidine
this drug induces uterine contraction
carboprost
hemabate
what drug is most likely to give you a stomach ulcer
ketorolac
this anti inflammatory drug would have a liver toxicity concern
celecoxib
water soluble prodrug
parecoxib
piperidines
5
meperidine fentanyl sufentanil alfentanil remifentanil
Diphenylheptanes
1
methadone
tramadol is a ?
racemic mixture of
r isomer partial mu agonist
s isomer blocks NE and serotonin uptake
tramadol cause cause resp depression T/F
t
eluxadoline is used for _____ and activiates______causing what 5 things
- diarrhea predominant IBS
- mu receptor on myenteric and submucosal neurons
1. reduce GI motility
2. reduced forward peristalsis
3. decreased GI mucus/juice secretion
4. increased circular contractions
5. increased fluid absorption
eluxadoline has a great or poor bioavailability
poor oral availability
