drug unique properties

Question 1

Which two drugs cause histamine release

Answer 1

morphine and meperidine

Question 2

This drug has a long half life and is used to treat opioid addicts by removing them from the places and people that inspire them to use

Answer 2

methadone

Question 3

This drug can be subdermal implanted lasting 6 months

Answer 3

buprenorphine

Question 4

These two drugs have a lower abuse potential because of being a mixed agonist-antagonist

Resp depression?

Answer 4

buprenorphine butorphanol

yes

Question 5

this drug will cause resp depression, sedation, drowsiness, dysphoria, psychotomimetic effects, but has lower abuse potential
IV only

Answer 5

butorphanol

Question 6

This drug can revers opioid induced urinary retention and reverse fentanyl induced resp depression while maintaining some pain relief, but might make the patient crazy

Answer 6

nalbuphine

Question 7

This drug is long acting mu kappa delta antagonist,

can be taken orally, used to treat delayed resp depression, used to treat opioid addiction.

Answer 7

naltrexone

can cause severe withdrawals

Question 8

This drug is quintenary amine and is used to treat OIC

Answer 8

methylnaltrexone

Question 9

this drug is a GI specific opioid receptor antagonist
broken down in intestine, treats OIC
doesn’t cross BBB so doesn’t decrease pain relief

Answer 9

alvimpoan entereg

Question 10

this is the least lipophilic opioid

Answer 10

morphine

Question 11

structurally similar to atropine

Answer 11

meperidine

Question 12

this drug is metabolized into an excitatory metabolite that would be bad for a patient hepatic issues or on mao inhibitor
can cause serotonin syndrome(hypothermia, delirium, convulsion

Answer 12

meperidine

Question 13

10% unionized in plasma

Answer 13

fentanyl

Question 14

highly protein bound opioid, toxic for elderly

Answer 14

fentanyl

Question 15

Renal failure patients would want to avoid what two opioid drugs

Answer 15

morphine meperidine

Question 16

this drug induces uterine contraction

Answer 16

carboprost

hemabate

Question 17

what drug is most likely to give you a stomach ulcer

Answer 17

ketorolac

Question 18

this anti inflammatory drug would have a liver toxicity concern

Answer 18

celecoxib

Question 19

water soluble prodrug

Answer 19

parecoxib

Question 20

piperidines

5

Answer 20

meperidine
fentanyl 
sufentanil
alfentanil 
remifentanil

Question 21

Diphenylheptanes

1

Answer 21

methadone

Question 22

tramadol is a ?

Answer 22

racemic mixture of
r isomer partial mu agonist
s isomer blocks NE and serotonin uptake

Question 23

tramadol cause cause resp depression T/F

Answer 23

t

Question 24

eluxadoline is used for _____ and activiates______causing what 5 things

Answer 24

• diarrhea predominant IBS
• mu receptor on myenteric and submucosal neurons
  1. reduce GI motility
  2. reduced forward peristalsis
  3. decreased GI mucus/juice secretion
  4. increased circular contractions
  5. increased fluid absorption

Question 25

eluxadoline has a great or poor bioavailability

Answer 25

poor oral availability