Upper GI Flashcards

1
Q

Difference between gastritis and PUD?

A

Gastritis = histological presence of gastric mucousal inflammation

Ulcer: break in the mucousal lining of the stomch or duodenum with depth to the submucosa >5mm

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2
Q

Main causes of PUD?

A

H.Pylori as increased inflammatory response and mucousal permeability

NSAIDs = decrease gastric mucousal blood flow = loss of protective barrier

Zollinger-ellsion syndrome
Bisphosphonates, infections e.g. CMV, ICU stay >48hours, Crohns and idiopathic

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3
Q

What is Zollinger-Ellison syndrome?

A

Gastric acid hypersecretion by gastrin-secreting neuro-endocrine tumour.

PC: abdo pain, diarrhoea and multiple recurrent duodenal ulcers

HPC = MEN

Ix = Inreased fasting serum gastrin level >1000pg/ml

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4
Q

PC for PUD/Gastritis?

A

Abdo pain = POINTING SIGN
Related to eating
Nocturnal

N+V
Early satiety
Weight loss
Diarrhoea (think Zollinger)

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5
Q

Main tests for PUD/Gastritis?

A

H.Pylori (1st line) via urea breathe test or stool antigen

OGD (gold standard)

FBC = low Hb = anaemia, bleeding ulcer

IF Dyspepsia +>60 or weight loss +>55 = OGD 1st line

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6
Q

What is the treatment for H.Pylori?

A

Triple therapy
PPI = omeprazole
Clarithromycin
Amoxicillin (or metronadizole

Discontinue NSAIDS

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7
Q

How to manage acute bleeding in PUD/Gastritis?

A

OGD: adrenaline. clips and thermocoagulation

Use Blatchford score for patient needs
Rockall score for severity of GI bleeding

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8
Q

Difference where the ulcer is in PUD?

A

Gastric = 5-6th decade peak, NSAIDS>H.Pyloir, pain shortly after eating

Dueodenal = 4-5th decade peak, H.Pylori?NSAIDS, pain a few hours after eating and may radiate to the back

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9
Q

RFs for PUD?

A

Poor diet, NSAIDS< smoking, increasing age, high alcohol

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10
Q

Pathology of GORD?

A

Relaxation of LOS so reflux of grastric contents into the oesophagus

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11
Q

RFs for GORD?

A

OBESITY, HIATUS HERNIA, alcohol, smoking, Fhx, ol age, NSAIDS< acidic food e.g. coffee, mints, citrus

CCB can cause LOS relaxation

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12
Q

PC For GORD?

A
Heartburn (after meals and worse lying down or bending over)
Acid regurgitation (bitter taste and after eating/waterbrash)

Other = dysphagia, bloating early satiety, laryngitis, halitosis and dyspepsia

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13
Q

Ix for GORD?

A

PPI trial for 8 weeks is 1st line

If persistent then DDx so OGD, oesophageal manometry and barium swallow

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14
Q

GORD management?

A

PPI trial for 8 weeks
Lifestyle changes: weight loss, bed elevation, avoid late ight eating, avoid chocolate, caffeine alcohol and acidic spicy foods

Adjuntc: H2 antagonists

Persistent GORD = fundoplication surgery

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15
Q

What are the complications of GORD?

A

Ulcer, bleeding, perforation, BArrets -> adenocarcinoma

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16
Q

Histology of Barrets?

A

Squamous epithelium -> columnar epithlium + intestinal metaplasia + goblet cells

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17
Q

RFs for Barrets?

A
Same as GORD
GORD
obesity
smoing
FHx
Age
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18
Q

PC for Barrets?

A

Same as GORD with heartburn and regurgitation

Dysphagia (may indicate malignancy)
CHest pain

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19
Q

Ix for Barrets?

A

OGD + Biopsy = diagnostic
(show salmon colour mucosa and columnar lined epitheliun)

Barium oesophogram (if dysphagic)

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20
Q

Barrets management?

A

PPI + surveillance

Endoscopic ablation or resection
Fundoplication as anti-reflux surgery
Oesophagectomy

21
Q

WHat is a hiatal hernia and types?

A

protrusion of the stomach through an enlarged oesophageal hiatus on the diaphragm

1 = sliding (most common 90%)
2 = para-oesophagela hernia/rolling
3 = mixed: sliding + rolling
4= giant hernai +stomach + 1 more structure)
22
Q

RFs for hiatal hernia>

A

OBESITY, previous gastro-oesophageal proceudres
Elevated intra-abdomincal pressure
PMH of other hernias

23
Q

PC of hiatus hernia?

A

GORD like: Heartburn, regurgitation, chest pain, dysphagia, odynophagia, haematemesis, SOB

Bowel sounds in chest and oropharyngitis

24
Q

Ix for hiatal hernia?

A

CXR: retrocardiac air bubble = OSCE buzz

Upper GI series = barium swall / criterion test

OGD for dysplasia

CT/MRI for other patholgies

25
Management of hiatus hernia?
Lifestyle changes (1st line) = lose weight. elevate bd rest, avoid largem emas, avoid alcohol, acid foods PPI Correct defect = fundoplication (nissen = 360, Toupet = 270, Watson = 180
26
Complication of hiatus hernia?
Obstruction, volvulus, Upper GI bleed, irreversible necrosis or ischaemia of stomach
27
Gastric cancer type and RFS?
Most common = adneocarcinoma Smoking, H.pylori, diet (salt, kow fruit and veg) Familial, EBV infection and pernicious anaemia
28
PC for gastric cancer?
``` ABdo pain (epigastric and vague) FLAWS ``` ``` Lymphaenopathy (Virchows) Sister mary joseph node = periumbilical Irish node (left axillary) ```
29
Gastric cancer Ix?
OGD and biopsy = 1st line ``` EUS + FNA CT/abdo pelvis for staging CXR PET Cancer = CEA or Ca19-9 ```
30
What is the pathophysiology behind Achalasia?
Normally = inibitoary neurones release NO for LOS relaxation Achalasia = loss of ganglion cells in myenetric pleux leads to series of inflammatory responses ending in destruction of post-ganglionic inhibitory neurones which contain NO so no NO or LOS relaxation
31
RFs for achalasia/
``` Autoimmunity Chagas disease Genes fro RH Allgrove syndrome Allgroves has triad of oesophageal achalasia, alacrime and adrenal insufficiency due to ACTH insensitivity ```
32
Features of Chagas disease?
AKA American trypanosomiasis by parasirt trypanosoma cruzi Latin america Associated with poverty and poor housing and apread by urine, faeces of kissingbugs?
33
PC of Chagas?
Dysphagi or liquids and solids and Odynophagia (also oesophageal cancer PC) Hepatosplenomgealy Abdo pain Jaundice
34
Achalsia PC?
``` Dysphagia to liquids and solids Posturing to aid swallowing Restrosternal pressure/pain Regurgitation different to GORD Weight loss = gradual/mild ```
35
Achalasia Ix?
OGD + Biopsy = 1st line Barium swallow = BEAK sign, loss of peristalsi and delayed emptying High resolution manometry = diagnositc CXR = absence of gastric bubble and dilated oesophagus
36
What is the pathophysiology of a Mallory-weiss tear?
``` Anything that increases intrabadominal pressure Vomiting (alcoholism) Coughing Straining Hiccups Trauma ```
37
RFs for Mallory-weiss tear?
ANy condition predisposing to vomiting, coughing, retchingm straining Hiatal hernia Significant alcohol use PMH or recent endoscopy
38
PC of MW tear?
Haematemesis Light headedness Posturla hypotension dysphagia, odynophagia, pain, haematochezia, shock, anaemia signs
39
OSCE haematemesis questions?
How many times, has it happened before, quantify bloods, what colour, associated pain and stool changes
40
IX for MW tear?
``` ABC 1st FBC (anaemia)and LFT for alocholic Cross match CXR - normal OGD is diagnostic ROCKALL score ```
41
Management for MW tear?
IV PPI Anti-emetics 1st line endoscopy = adrenaline injection and band ligation. Maybe thermal, haemoclips or thermocoagulation 2nd line= Sengstaken-blakemore tube Surgery = last cALL
42
What is a boerhaves perforsation?
Complication of MW tear and surgical emergency. Spontaneous due to force and RF = alcphl and obesity. Retrosternal chest pain and crackling sounds on examination with decreased breath sounds Pneumomediastiunnum on xray and needs surgery
43
what mediastinal structures can oesophageal cancer invade?
Trachea, bronchial tree, aorta, recurrent laryngeal nerve | Lungs, livers, lymph nodes
44
RFs for oesophageal cancer?
GORD and Barrets oesophagus Smoking, alcohol and obesity Diet low in fruit and veg Fhx f upper Gi cancers
45
Types of oesophageal cancers?
Squamous cell = 15% and upper 2/3rds of oesophagus. RFs = smoking, alcohol and HPV Adenocarcinoma = 80% and lower 1/4 and LOS. RF = chronic GORD amd barrets, obesity and diet. Others = 5%
46
PC of oesophageal cancer?
``` Dysphagia Odynophagia Reflux Weight loss and FLAWS Hoarse voice from recurrent laryngeal nerve invasion Hiccups from phrenic nerve invasion ```
47
Oesophageal cancer Ix?
1st line = OGD and biopsy with biopsy as diagnostic | Metabolic profile and CT chest abdo, MRI for mets and PET scan
48
Oesophageal cancer management?
Early diagnosis = oesophagectomy Intramuousal lesion = OGD removal Late = CHemo +-radiotherapy + resection