Untitled Deck Flashcards
What is the primary pharmacologic treatment for managing menopausal symptoms?
Hormone Therapy (HT) is the first-line treatment, especially for hot flashes and vasomotor symptoms.
When is estrogen-alone therapy (ET) recommended?
ET is recommended for women without a uterus.
What type of hormone therapy is used for women with an intact uterus?
Estrogen-Progestogen Therapy (EPT) is used to prevent endometrial complications.
Why is progestogen necessary in hormone therapy for women with a uterus?
Progestogen prevents endometrial hyperplasia or cancer by counteracting estrogen’s stimulatory effects on the uterine lining.
What are some commonly used progestins in hormone therapy?
Medroxyprogesterone acetate (MPA), norethindrone acetate, and native progesterone are commonly used.
When is local (topical) estrogen therapy indicated?
Local estrogen therapy is indicated for vaginal dryness as the primary symptom.
Why doesn’t local estrogen therapy require progestogen?
Low-dose local estrogen does not raise systemic estrogen levels enough to stimulate the uterine lining.
What is the role of Bazedoxifene in hormone therapy?
Bazedoxifene, combined with conjugated estrogens (CEE), provides endometrial protection without needing additional progestogen.
How does systemic estrogen therapy benefit menopausal women?
Systemic estrogen therapy alleviates broader symptoms, such as hot flashes and vasomotor symptoms, by raising blood estrogen levels.
Why is estrogen-progestogen therapy necessary for systemic HT in women with a uterus?
It prevents estrogen-induced risks of endometrial hyperplasia or cancer.
How does local estrogen therapy benefit vaginal dryness?
Local estrogen directly addresses vaginal dryness without systemic effects or the need for progestogen.
What is the primary benefit of using Bazedoxifene with conjugated estrogens?
It combines estrogen benefits with endometrial safety, eliminating the need for additional progestogen.
What are the benefits of customizing hormone therapy for menopausal symptoms?
Systemic HT addresses widespread symptoms like hot flashes, while local estrogen targets specific symptoms like vaginal dryness without systemic effects.
When is systemic unopposed estrogen therapy indicated?
Systemic unopposed estrogen is prescribed for women who do not have a uterus.
What is the purpose of local estrogen therapy?
Local estrogen therapy is used to treat vaginal symptoms like vaginal atrophy and dryness, regardless of uterine status.
Why is local estrogen therapy considered safe for all women?
Local estrogen does not raise systemic estrogen levels significantly, eliminating the need for additional progestogen.
Why is progestogen added to estrogen therapy in women with an intact uterus?
Progestogen prevents endometrial hyperplasia and reduces the risk of endometrial cancer caused by unopposed estrogen.
What is the role of Estrogen-Progestogen Therapy (EPT)?
EPT provides the benefits of estrogen while ensuring endometrial protection for women with an intact uterus.
What happens if unopposed estrogen is given to women with a uterus?
It can stimulate the uterine lining, increasing the risk of endometrial hyperplasia and cancer.
Why is systemic unopposed estrogen therapy unsuitable for women with a uterus?
Without progestogen, it increases the risk of endometrial cancer due to estrogen stimulation of the uterine lining.
What symptoms does local estrogen therapy specifically target?
Local estrogen therapy targets vaginal atrophy and dryness.
How does EPT balance the effects of estrogen?
EPT allows the benefits of estrogen while reducing its risks by protecting the endometrium in women with a uterus.
What is the primary benefit of using progestogen in EPT?
Progestogen prevents adverse effects of unopposed estrogen, such as endometrial hyperplasia and cancer.
What is the first-line therapy for managing vasomotor symptoms (VMS) in menopausal women?
Hormone Replacement Therapy (HRT) is the first-line therapy for managing hot flashes and other vasomotor symptoms.