Unit Six/Eight: Metabolism And Energy And Immunity Flashcards
Conservation of energy
Energy cannot be created or destroyed, but it can be changed from one form to another
What are the forms and types of energy?
Potential or stored energy
Kinetic or energy in motion
Second law of thermodynamics
Every energy transformation makes the universe less organized and more disordered
Heat
The energy if random molecular movement in which half of energy is lost as
Entropy
Used to indicate the relative amount of disorganization
Metabolism
All the chemical reactions that occur in a cell. They can be divided into catabolism and anabolism
Catabolism
Breaking down reactions
Anabolism
Building reactions
Free energy
(G) the amount of energy available or still free to do the work
How is the change in free energy calculated?
By subtracting the free energy content of the reactants from that of the products
Exergonic reactions
(- change G)?energy released, occurs spontaneously
Endergonic reactions
(+ change G) products have more free energy than the reactants with an input of energy
Coupled reactions
Exergonic reactions is used to drive endergonic reactions
Activation energy
Energy that must be added to cause molecules to react with one another
What lowers activation energy?
Catalysts
Structure of an enzyme
Protein molecules that put stress on chemical bonds, lower activation energy required to speed up chemical reactions
Active site
Globular proteins that have a depression
Substrate
Molecule an enzyme acts on
What factors effect enzyme activity?
Temperature, ph, substrate concentration,enzyme concentration
Temperature affecting enzymes
Too cold creates a rigid bond with no induced fit and too jot denatures an enzyme when the peptide bond fails
Ph affecting an enzyme
Too extreme denatures an enzyme
Substrate concentration affecting an enzyme
Reaction rate will level off as substrate is available
Enzyme concentration affecting an enzyme
Reaction rate increases until all enzyme is used
No competitive inhibition
Binding of a inhibitor at a site outside of the active site changes the shape of the enzyme (allosteric change) so that substrate can’t bind to the enzyme. Product inhibits enzyme which creates it
Competitive inhibition
Binding of an inhibitor at the enzymes active site which inhibits the reaction with the substance
Activation
Binding of an activator at the site outside of the active site enables binding of substrate to the active site, activating the reaction
Coenzymes
Pass electrons from active site to active site In redox rxns, such as NAD+ to NADH in cell respiration or NADP+ to NADP in photosynthesis
Oxidation
Loss of electrons
Reduction
Gain of electrons
What is ATP used for?
Chemical, transport, and mechanical work
How is ATP created and what is its structure?
Using ADP by adding a phosphate group through hydrolysis so the structure is adenosine and three phosphate to allow it to carry and be able to release as much energy by high energy electrons passed down a series or carriers
Substrate level phosphorylation
The synthesis of ATP by reactions in which ADP is used
Chemiosmosis
The movement of ions across a selectively permeable membrane down their electrochemical gradient
Digestion
Ingests food
Digests food
Absorbs molecules
Eliminates waste
Incomplete digestion
One opening for taking in food and eliminating waste (extra cellular and intracellular)
Extracellular
Digestion by enzymes in the digestive tract
Intracellular
Occurs in cells lining the digestive tract
Complete digestion
Two openings, mouth and anus, and all is extra cellular
Chemical digestion
Breaks down food by enzymes and hydrochloric acid
Mechanical digestion
Breaks down food by teeth and by churning of stomach and small intestine
Pathway of food
Mouth (chews food and digests starch)
Pharynx
Esophagus (moves by peristalsis)
Stomach (stores food and acidity kills some bacteria and digests proteins)
Small intestine (digests foods and absorbs nutrients)
Large intestine (absorbs water)
Anus (releases waste)
What are the accessory organs?
Pancreas, liver, gallbladder
Pancreas exocrine gland
Releases digestive enzyme and sodium bicarbonate into the small intestine
Pancreas endocrine gland
Releases hormones into the blood stream to regulate blood sugar
Liver
Produces bile
Gallbladder
Stores it
Maximum surface area related to the structure of the small intestine
Creates faster adsorption
Structure of a virus
DNA/RNA surrounded by a capsid protein coat
Virus and a host
A virus injects a host cell and replicates itself
Lytic cycle
Viral DNA or RNA is injected into the host cell where it directs the synthesis of more of the viral genome and more viral capsids which are then assembled inside the host cell. The cell to rupture releasing the newly produced viruses.
Lysogenic cycle
Viral DNA is integrated into the host cell DNA and may be carried for years or may switch to the lyric cycle. While latent the viral DNA is called prophase
Bacteriophage
Virus that infects bacteria
Viroids
Naked strands of RNA that cause crop disease
Prions
Newly discovered disease agents that vary from viruses and bacteria
Structure of a prokaryotic cell
Cell wall, DNA and RNA and some have flagella
How is a bacterial cell wall different from other cell walls?
It has peptioglycan
How do prokaryotes produce?
Binary fusion
Conjugation
Genes transform from one bacteria to another by sex pili
Transduction
Genes are transferred between bacteria by a bacteriophage
Transformation
Genes are taken up from the surrounding environment
What are some archaea?
Methogens
Halophiles
Acidophiles
Thermophiles
Archaea
Occur in extreme conditions and are prokaryotes
Gram positive
Cell wall contains a thick layer of peptidoglycan
Gram negative
Cell wall has only a thin layer of peptidoglycan
Modes of nutrition for a prokaryotic cell
Photo autotrophs (use sun and gives off oxygen) Photo heterotrophs (use light and organic matter) Chemo autotrophs (carry out chemosynthesis) Chemo heterotrophs (take in organic matter) Saptotrophs (decompose organic molecules)
Non-specific defense
React to anything foreign and to tissue damage. Is the body’s first response and involves no memory of specific pathogens.
Specific defense
Responds to specific pathogens or antigens and remembers antigen for a future attack
Physical barriers
Non-specific pathogen, skin, mucous membranes, ciliated membranes
Chemical defense
Non-specific defense, kills microbes with lysozyme s found in saliva, sweat, and tears and acid like HCL from digestion and skins oil and sweat lowering the ph
Inflammatory response
Non-specific defense, histamines cause blood vessels to dilate around injury to attract more immune cells , mast cells are white blood cells in connective tissue that release chemical alarms causing dilation to attract phagocytes
Phagocytes
Kills microbes, non-specific defense
Microbes
Type of blood cell
Macrophages
Big eater that ingest bacteria by end oxytocin, phagocytes
Neutrophils
Phagocytes, ingest bacteria and then release bleach like substance to kill pathogen and themselves
Natural killer cells
Kill abnormal cells by puncturing the membrane to kill microbes and cause cancer
Major histocompatibility complex
Glycoprotein marker that identifies self from non-self by MAC killing non-self microbes, amplifying other responses, macrophages send signal to hypothalamus increasing temperature causing increase in phagocytosis and inhibits microbe growth
Lymphocytes
White blood cells involved in the body’s specific immune response (T and B cells)
Cell mediated response
Macrophage binds to antigen and presents it to a T cell with the matching antigen receptor to be copied thousands of times to create helper, killer/cytotoxic, and memory t cells
Helper T-cells
Initiate immune response by releasing chemicals that stimulate phagocytosis and promote clonal expansion of T and B cells
Killer/cytotoxic T-cells
Puncture infected body cells and insert performing to lysis
Memory T-cells
Remain in blood stream for future immunity
Humoral response
Long range defense initiated by T-cells
B cell with the appropriate antigen receptor binds to antigen stimulates proliferation and clones itself resulting in plasma and memory B cells
Plasma cells
B cells that produce antibodies to fight infection
Memory B cells
Cells that remain in the body for future immunity . They will quickly produce plasma cells in the body if infected by the same pathogen again
Antibody
Specific antigen binding site in 2 arms of the Y to fight an infection
Clonal expansion
Copied many times to aid specific defense
Primary immunity
First time infected several days for B cells to proliferate
Secondary immunity
Memory cells react to the antigen faster the second time the infection occurs
Active immunity
Persons own immune system (naturally or artificially induced)
Passive immunity
Temporary immunity not involving individuals own immune system (common in babies)
Vaccines
Triggers the production of antibodies, Jenner used cowpox for small pics and Pasteur weakened cholera in chickens
Disorders of the immune system
Aids or HIV
Allergies
Auto-immune diseases (immune system turns on self)