Unit 8: Disease of the Blood, the Heart, and Blood Vessels Flashcards
WBC (White Blood Cells)
Leucocytes
RBC (Red Blood Cells)
Erythrocytes
Platelets
Thrombocytes
Produced in red bone marrow
-Function: blood cloting
Platelets
increase in number of WBC in blood
- Most Common: may be physiological
- Pathological
Leucocytosis (Luekocytosis)
abnormal reduction in number of WBC in blood
-usually due to damage to bone marrow or lymphatic tissue
Leucopenia (Leukopenia)
- Anemia
- Infections
- Bleeding
- Bruising
Results of Leucopenia
associated with formation of blood and blood components
Hematopoietic (Hemopoietic) Disorders
literally means “white blood”
-cancer of the WBC pro ducting structures/organs
Leukemia
Results in production of immature WBC
- # 1 cause of cancer and cancer deaths in children
- 20%-70% survival rate
Leukemia
in children
Acute Leukemia
in adults
Chronic Leukemia
800,000 cells
- granulocytes (neutrophils) in high numbers
- may be caused by exposure to radiation
- results in anemia, remissions are common
Granulocytic Leukemia
200,000 cells
- may be caused by viruses
- cause severe anemia, pneumonia, infections
- Remissions are common 80%+ survival rate
Lymphocytic Leukemia
50,000-200,000 cells
- may be caused by chemicals
- higher risk of Severe Infections (less of anemia)
- Remissions are rare
- higher Death rate.
- 25% survival rate
Monocytic Leukemia
most common in children ages 3-6
Lymphocytic Leukemia
bone marrow makes too many RBS causing thickening of blood > slow blood flow
- greater risk of forming blood clots
- enlarged spleen
Polycythemia Vera (primary polycythemia)
increase in number of RBC in blood (increased hematocrit)
-rare
Erythrocytosis
- Hereditary condition
- Excess blood in transfusion
- Underactive spleen (removes and destroys old RBC)
Erythrocytosis Etiology
May result in:
- Plethora (too much blood)
- higher risk of forming blood clots/thrombi
- Congestive Heart Failure
- Ischemia
- Cyanosis (lack of oxygen)
- Enlarged spleen
Erythrocytosis Results
decrease number of RBC in blood (decrease hematocrit),
Erythrocytopenia
May result in
Anemia-decrease in normal number of RBC or quantity of hemoglobin in blood leading to > decrease in oxygen delivery > loss of energy
Erythocytopenia Results
chronic, hematologic disease (concerned with blood or blood forming structures)
-Low hemoglobin level
Anemia
develops as a complication of another disease
- Nonhematologic disease
- Longer than 2-6 months
Secondary Anemia
RBCs are being destroyed
Increased Destruction Anemia
producing less RBCs than normal
Decreased Production Anemia
- Hemorrhage
- Injury or trauma
- Genetic
- Infections
Increased Destruction Anemia Etiology
Genetic mutation resulting in hemoglobin S
-cells of weird shape, form clots > spleen traps and destroys them
Sickle Cell Anemia (Primary)
Results in:
- Tachycardia
- Fatigue
- Dyspnea
Sickle Cell Anemia Results
Mom and baby have different blood types
Common Condition
Erythroblastosis Fetalis (primary)
Babys RBCs are immature and larger than normal
-may form blood clots > trapped in spleen and destroyed
Erythroblastosis Fetalis (primary)
Overactive spleen due to mononucleosis or liver cancer
-may cause splenomeagaly
Hypersplenism (secondary)
Underactive bone marrow due to:
- radiation
- chemical poisons
- leukemia or bone cancer (osteosarcoma)
Decreased Production Anemia Etiology
Chemical poison (lead or mercury) > damages bone marrow
Chlorosis
- damage to bone marrow of unknown origin (idiopathic)
- bone marrow suppressed, does not produce enough, or any, blood cells
- could be due to chemicals, radiation, infection, or metabolic disorders
Decreased Production Anemia Etiology
-vitamin B12 deficiency
Pernicious Anemia
- Due to lack of intrinsic factor in stomach
- Common in women following childbirth or malnutrition disorder
Pernicious Anemia
deficiency of B12 and folic acid
Megaloblastic Anemia
large blood cells
Megaloblasts
Associated with Pernicious Anemia
Megaloblastic Anemia
decrease in number of platelets
-less than 60,000 platelets
Thrombocytopenia
Due to damaged bone marrow
-radiation, chemicals, cancer (leukemia)
Thrombocytopenia
Results in decreased ability to clot or coagulate blood
- bruise and bleed easily > resulting in hemorrhage
- bruising > purple discoloration > immune thrombocytopenia purpura
Thrombocytopenia
immune system destroys its own platelets
Bleeding Disorder: Immune Thrombocytopenia Purpura
Spontaneous bleeding in subcutaneous tissues > purple patches on skin
-acute pediatric viral illness
Bleeding Disorder: Immune Thrombocytopenia Purpura
X-Linked (more common in males) or somatic inherited hemorrhage disease
Hemophilia
abnormal or absent clotting factor > inability to clot blood
Hemophilia
- excessive, prolonged, sometimes spontaneous bleeding
- frequent epistaxis (nosebleeds), bruising
- severe Hemophilia
Hemophilia Symptoms
bleeding into joint
Hemarthrosis