Unit 4 (Week 13 Patterns of Inheritance) Flashcards
What is the transmission of characteristics from parent to offspring?
Inheritance
What was the idea that the determinants of hereditary traits are transmitted in discrete units, or particles, from one generation to the next?
Particular inheritance
[Information on Different Types of Mendelian Inheritance Patterns and Their Molecular Basis]
Simple Mendelian inheritance
Inheritance pattern: Pattern of traits is determined by a pair of alleles that display a dominant/recessive relationship and are located on an autosome. The presence of the dominant allele masks the presence of the recessive allele.
Molecular basis: In many cases, the recessive allele is nonfunctional. Though a heterozygote may produce 50% of the functional protein compared with a dominant homozygote, this is sufficient to produce the dominant trait.
X-linked inheritance
Inheritance pattern: Pattern of traits is determined by genes that display a dominant/recessive relationship and are located on the X chromosome. In mammals and fruit flies, males are hemizygous for X-linked genes. In these species, X-linked recessive traits occur more frequently in males than in females.
Molecular basis: In a female with one recessive X-linked allele (a heterozygote), the protein encoded by the dominant allele is sufficient to produce the dominant trait. A male with a recessive X-linked allele does not have a dominant allele and does not make any of the functional protein.
Incomplete dominance
Inheritance pattern: Pattern that occurs when the heterozygote has a phenotype intermediate to the phenotypes of the homozygotes, as when a cross between red-flowered and white-flowered plants produces pink-flowered offspring.
Molecular basis: Fifty percent of the protein encoded by the functional (wild-type) allele results in an intermediate phenotype.
Codominance
Inheritance pattern: Pattern that occurs when the heterozygote expresses both alleles simultaneously. For example, a human carrying the A and B alleles for the ABO antigens of red blood cells produces both the A and the B antigens (has an AB blood type).
Molecular basis: The codominant alleles encode proteins that function somewhat differently from each other. In a heterozygote, the function of each protein affects the phenotype uniquely.
Epistasis
Inheritance pattern: A type of gene interaction in which the alleles of one gene mask the effects of an allele of another gene.
Molecular basis: Two different genes are needed to produce a given phenotype. Loss of function of one of the genes alters the phenotype.
Continuous variation
Inheritance pattern: A pattern in which the offspring display a continuous range of phenotypes.
Molecular basis: This pattern is produced by the additive interactions of several genes, along with environmental influences.
None
[Start 17.1 Mendel’s Laws of Inheritance]
In 1856, Gregor Mendel began his historic studies on what plant?
How long did he analyze this plant?
What was the name of his published paper in 1866?
Why was his paper ignored by peers?
Pea plants.
8 years!
“Experiments on Plant Hybrids”
His paper was largely ignored because of the title.
What is the process in which two individuals of the same species with different characteristics are bred or crossed to each other; the offspring are referred to as hybrids?
Hybridization
What was Mendel particularly intrigued by?
The consistency with which offspring of such crosses (different characteristics of plants in the same species) showed characteristics of one or the other parent in successive generations.
How did Mendel, with a foundation in physics and natural sciences, lead him to uncover the naturals laws governing inheritance?
He carried out quantitative experiments in which he carefully analyzed the numbers of offspring carrying specific traits.
What is a characteristic of an organism, such as the appearance of seeds, pods, flowers, or stems in the garden pea?
Called a character.
Why did he choose this species? Several properties of the garden pea were particularly advantageous for studying inheritance. First, it was available in many varieties that differed in characteristics.
What is an identifiable characteristic; usually refers to a variant?
Trait
What was another advantage of studying the pea plant?
They are normally self-fertilizing.
What is fertilization that involves the union of a female gamete and male gamete from the same individual?
Self-fertilization
What is a strain that continues to exhibit the same trait after several generations of self-fertilization or inbreeding?
True-breeding line
What was the third reason why pea plants were used in hybridization experiments?
Ease of making crosses: The flowers are fairly large and easy to manipulate. In some cases, Mendel wanted his pea plants to self-fertilize, but in others, he wanted to cross plants that differed with respect to some character, a process called hybridization, or cross-fertilization.
What is cross fertilization?
Fertilization that involves the union of a female gamete and a male gamete from different individuals.
Why are the stamens removed from the purple flower in this cross-fertilization procedure?
The stamens are removed from the purple flower to prevent self-fertilization.
What is a cross in which an experimenter follows the variants of only one character?
Single-factor cross
As an example, we will consider a single-factor cross in which Mendel followed the tall and dwarf variants for height
What does P generation mean?
The parental generation in a genetic cross.
What does F1 generation mean?
The first generation of offspring in a genetic cross.
What is the The F1 offspring, also called single-trait hybrids, of true-breeding parents that differ with regard to a single character?
A monohybrid.
Why do offspring of the F1 generation exhibit only one variant of each character?
The reason why offspring of the F1 generation exhibit only one variant of each character is because one trait is dominant over the other.
How is the second generation of offspring in a genetic cross denoted?
F2 generation
What was the three important ideas that Mendel postulated about the properties of traits and their transmission from parents to offspring?
- Traits may exist in two forms, dominant and recessive.
- An individual carries two genes for a given character, and genes have variant forms (now called alleles).
- The two alleles of a gene separate during the process that gives rise to haploid cells and gametes, so each sperm and egg receives only one allele.
What are the alternative traits described as?
Dominant and recessive
What refers to the trait that is displayed in a heterozygote?
Dominant