Unit 4 Part 8: Introduction to fungi of medical importance Flashcards

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1
Q

is fungi usually considered more or less dangerous then bacteria and viruses

A

less

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2
Q

does fungi usually cause disease in healthy people

A

rarely

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3
Q

what is fungi commonly used in (3)

A

medicine
food and beverage production
biotechnology

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4
Q

what 2 conditions promote fungal growth

A

darkness and moisture

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5
Q

are fungi eukaryotes or prokaryotes

A

eukaryotes

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6
Q

what are single celled fungi called?

what are multi-cell fungi called

A

single celled: yeasts

multi-cell: molds

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7
Q

what term is given to pathogenic fungi that alter between both single and multi-cell forms

A

dimorphic fungi

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8
Q

dimoprhic fungi are considered

A

true pathogens

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9
Q

what dimorphic fungi causes histopalsmosis in humans

A

histoplasma capsulatum

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10
Q

what organ does histoplama usually invovle

A

lungs

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11
Q

where does histoplasma usually grow

A

as mold in the soil and yeast in animal and human hosts (temperatue dependent)

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12
Q

2 features of opportunistic fungi

A

low virulence

typically pathogenic to immunocompromised hosts

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13
Q

do dimorphic or opportunistic fungi usually have geographic distribution

A

dimorphic

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14
Q

what is the study of medical mycology

A

study of fungi that cuase human disease

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15
Q

what is another term of fungal diseases

A

mycoases

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16
Q

what is the classification of mycoses based on

A

level of tissue involvemnet

mechanism by which the fungi enter the body

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17
Q

what are the two sources of fungus

A

endogenous and exogenous

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18
Q

what is the classification of endogenous pathogens

A

opportunistic

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19
Q

what is the source of endogenous opportunistic fungal infections

A

latogenic (means medical treatment)

(e.g. indwelling lines, catheters, etc.)

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20
Q

exogenous fungal infections that can be classified as superficial, cutaneous or subcutaneous are usually caused by

A

trauma

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21
Q

exogenous fungal infections that are classified as systemic or opportunistic are often caused by

A

inhalation

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22
Q

superficial mycoses usually infects what area of the body

A

outermost layer of the skin and hair, they do not invade living tissues

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23
Q

what type of mycoses is tinea capitis

A

superficial mycoses

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24
Q

what is tinea capitis

A

syperficial mycoses

infection of the hair follicles on the scalp and eyebrows

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25
Q

what are the S&S of superficial mycoses

A

itching
redness
crusted lesions
scaly scalp

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26
Q

what is the MR of superficial mycoses

A

humans

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27
Q

what is the modes of transmission for superficial mycoses

A

sharing/contact with contaminated articles or self-infection

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28
Q

what’s another term for cutaneous mycoses

A

dermatophytoses

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29
Q

where do fungi colonize in cutaneous mycoses

A

skin, hair and nails

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30
Q

do cutaneous mycoses have greater invasive properties than those causeing superfical mycoses

A

yes

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31
Q

what are the S&S of cutaneous mycoses

A

itchy

red roudn or oval lesions/rash, which may peel off the edges around the center fading

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32
Q

what are 3 examples of cutaneous mycoses

A

ringworm
atlehtes foot
jock itch

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33
Q

what is the MR for cutaneous mycoses

A

humans
soil
animals

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34
Q

what is the MT for cutaneous mycoses

A

PTP via

contact such as the shower floor or sharing contaminated hat or towel

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35
Q

other than humans what else can transfer cutaneous mycoses to humans

A

animal

soil

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36
Q

for subcutaneous mycoses how do fungi surive in the subcutaneous layers

A

produce proteolytic enzymes and maintaing a facultative microaerophilic environment

37
Q

what is an example of a subcutaneous mycoses

A

sporotrichosis

38
Q

where do subcutaneous mycoses often infect

A

arms and hands

39
Q

what are the S&S of subcutaneous mycoses

A

numerous nodules
abscesses
ulcerative lesions tha develop along the lympahtics
(original site drains into lymph nodes)

40
Q

what is the MR for subcutaneous mycoses

A

soil and decaying vegetation

41
Q

what is the MT for subcutaneous mycsoses

A

indirect transmission e.g. by punctures

42
Q

fungi are said to be ________ in that they can obtain nutrietns from decomposing dead organic matter

A

saprophytes

43
Q

systemic mycoses are caused by

A

disseminated fungal infections of deep tissues and/or organs

44
Q

what are the most servious and potentially life-threatening type of mycoses for elderly and immunocompromised

A

systemic mycoses

45
Q

where do systemic mycoses usually begin

A

infections of the respiratory tract

46
Q

what is the MR for systemic mycoses

A

soil

birds and bats droppings increase nitrogen levels in soil that promote growth of theses fungi

47
Q

what is the MT of systemic mycsoes

A

airborne inhalation of fungal spores

48
Q

what is the causative agent of the systemic mycoses blastomycosis

A

blastomyces dermatitidis

49
Q

what are the S & S of blastomycosis

A

flu-like symptoms that vary in degree dependent on how far it spreads

50
Q

where does blastomycosis originate

A

in the lungs then spread to parts of the body usch as skin, bones, joints and the CNS

51
Q

what is the IP for blastomycosis

A

30-45 days

52
Q

what are they signs and symptoms of the systemic opportunistic mycoses pneumocystis pneumonia

A
fever
mild/dry cough
SOB
fatigue
weight loss
Chest Pain
53
Q

what is one of the most frequent and severe opportunistic systemic mycoses infections in the immunocompromised

A

pneumocystis pneumonia

54
Q

what opportunistic mycoses is found in 70-80% of HIV+ patients

A

pneumocystis pneumonia

55
Q

what is the MR and MT of pneumocysiti pneumonia

A

unknown believed to be spread by PTP via direct contact

56
Q

what is the IP in pneumocystis pneumonia

A

3-12 weeks

57
Q

what is the opportunisitc mycoses: candidiasis (thrush)

A

infections of the mucous membranes of oral caivity and genital tract - creamy white lesions

58
Q

what is the causaitve agent of candidiasis

A

candida albicans

59
Q

what is the major resevoir for thrush

A

humans, candida is part of our normal biota

60
Q

what is the treatment for thrush

A

anti-fungal drugs such as nystatin mouthwash (oral thursh)

miconazole cream/suppository for Vaginal thrush

61
Q

what does candida mean

A

white - white colonies and white lesions

62
Q

what are risk factors for thrush

A

high estrogen levels
low progesterone levels
less competeion from mutualistic microbiota e.g broad spectrum antibiotics and chemo
diabetes

63
Q

what is the symptoms of VVC (vaginal thrush)

A
extreme itch
dysuria
thick discharge
vaginal discomfort
soreness
burning 
swelling
64
Q

what is the discharge for vaginal thrush

A

cottage cheese

65
Q

what are the symptoms of BV

A
odor
itch
discharge 
soreness
bruning
66
Q

what is the discharge for BV

A

thin,milky, fishy smelling

67
Q

what are the symptoms for trichomoinaiasis (STI)

A
odor
itch
discharge
soreness 
could be asymptomatic
68
Q

what is the discharge for trichominasis

A

frothy gray
or yellow/green
foul odor

69
Q

trichomoniasis clinical features

A

strawberry cervix
small red or purple spots from bleeding under the skin
swelling

70
Q

out of VVC, BV and trichomoniasis which one results in a positive KOH “whiff” test

A

trichomoniasis

71
Q

the opporunistic mycoses crytococcosis infects what

A

infection of lungs, meninges and/or skin

72
Q

what is the causative agent of the opportunist mycoses cryptococcosis

A
cryptococcus neoformans (CN) &
cryptococcus gatti (CG)
73
Q

what is the MR for cryptococcosis

A

environment, particularly trees, decaying woods, soils and bird droppings

74
Q

what is the MT for cryptococcosis

A

airborne/aerosols - inhalation of fungalspores

75
Q

what are the S & S of cryptococcosis

A
prolonged cough
SOB
headace
vomiting
fever 
weight loss
76
Q

cryptococcosis can lead to what

A

pneumonia or meningtisi

77
Q

what are nosocomial mycoses

A

outbreaks of mycoses in health care settings: airborne and construction related: airborne and construction-related

78
Q

what is the most common nosocomial mycoses

A

aspergilus aka “black mold”

79
Q

what is mycotoxicoses

A

fungal disease caused by ingestion of fungal toxins (mycotoxins)

80
Q

aflatoxins caused by aspergilus (black mold) can cause what

A

liver damage and cancer

81
Q

what is sick building syndrome

A

a condition affecting office workers, typically marked by headaches and respiratory problems attributed to unhealthy or stressful factors in the working environment such as poor ventilation

82
Q

what have been raised as possible causes of SBS

A

fungi and mycotoxins

83
Q

what type of symptoms cause sick builiding syndrome

A

allergy-like syndrome

84
Q

what are the toxic effects of aflatoxins

A

hepatotoxicity
bile duct hyperplasia
intestinal and renal hemorrhage
liver tumors

85
Q

what are the two main mycotoxicoses causing agents

A

aflatoxins

trichothecenes

86
Q

what are the toxic effects of trichotheceencenes

A
vomiting
diarrhea
bleeding
dyspnea
itching
rash
blisters
leukopenia
87
Q

what are type 1 HS

A

type 1 hypersensitivity

symptoms similar to hay fever and food allergy

88
Q

what is type 3 HS

A

woodworkers lung due to repeated exposure to allergins in wood pulp and dust

89
Q

what are the risk factors for allergy/hypersensitivity to fungi

A

genetic predisposition
excess humidity
tightly sealed and insulated homes
building leaks
lack of maintenance on air conditioners etc
occupation hazard e.g. those who work in the mill