Unit 3 Muscles Flashcards
Groups of muscle are covered by…
deep fascia
Muscle is covered by…
epimysium
Fascicle is covered by…
perimysium
Muscle fiber is covered by…
endomysium
Which cells do muscle “fibers” arise from?
Myoblasts
Hypertrophy
Increase in size
Hyperplasia
Increase in number
Can muscle fibers undergo mitosis?
No
What performs the conduction of electrical signals?
Sarcolemma
What controls muscle contraction?
Sacroplasmic reticulum
What allows for muscle contraction?
Myofibrils inside muscle fibers
Longitudinal bundles of protein filaments inside the muscle fiber
Actin and Myosin
Highly organized into repeating units
Sarcomeres
Contractile proteins
Actin and myosin
Regulatory proteins
Troponin and tropomyosin
Actin
- found in thin filaments
- has myosin binding sites for crossbridge formation
Myosin
- motor protein found in thick filaments
- head of myosin binds to the binding site on actin during muscle contraction
In which filament is actin found?
thin
In which filament is myosin found?
thick
Which part of myosin binds to the actin binding cite?
the head
Sarcomeres
Functional unit of contraction
The binding site on actin is covered by what?
regulatory proteins
Which muscle protein gives muscles elasticity and extensibility?
Titin
Which muscle protein helps the sarcomere return to its resting length?
Titin
What is a cytoskeletal protein that links thin filaments to the sarcolemma?
Dystrophin
Which muscle protein is attached to the extracellular proteins in the connective tissues surrounding the muscle fibers?
Dystrophin
Which muscle protein helps transmit tension from sarcomeres to tendons?
Dystrophin
Which muscle protein spans the length of the thin filament?
Nebulin
Which muscle protein anchors thin filaments to Z disc?
Nebulin
Which muscle protein is found in the Z disc?
α-actinin
Which muscle protein binds to actin molecules of the thin filament to titin?
α-actinin
Which muscle protein is found in the M line?
myomesin
Which muscle protein binds titin and thick filament to connect them together at the M line?
Myomesin
Myosin heads bind to actin to form a ________
crossbridge
Conformational change is energized by ________ to cause thin filaments to slide along thick filaments
ATP hydrolysis
As thick / thin filament overlap increases….
I band length decreases
A band length remains constant
H zone length decreases
Zone of overlap increases
the attached head group after the power stroke is called a _______
Rigor complex
Rigor mortis
the rigor of death because lack of ATP to detach the crossbridge
Functions of skeletal muscle
- locomotion
- facial expression
- heat production
Function of cardiac muscle
pump blood into systemic circulation
Functions of smooth muscle
- propel food
- mix food
The immediate source of energy to support development of tension
ATP
Hydrolysis by the myosin head group fuels _________
tension generation
Hydrolysis by the Ca-pump of the SR supports ________
relaxation
What are three ways ATP re-synthesizes?
- creatine phosphate
- anaerobic glycolysis
- aerobic metabolism
How long does ATP support force?
2 seconds
How long does creatine phosphate support force?
15 seconds
Creatine phosphate pool after a meal
ATP + C –> ADP + CP
Creatine phosphate pool during exercise
ADP + CP –> ATP + C
Small amino acid-like molecule
Creatine
Where is creatine synthesized?
Liver, kidney, and pancreas
Where is creatine transported?
Muscle fibers
In a relaxed muscle fiber what is 3-6x more plentiful than ATP
Creatine phosphate
How long does glycolysis support force?
2 minutes
Where does glycolysis occur?
Rapidly, cytoplasm
How long does aerobic respiration support contraction?
40 minutes to several hours
Fatigue is caused by
- glycogen depletion
- lactic acid buildup
- phosphate buildup from creatine phosphate metabolism
- potassium accumulation
What structural muscle protein spans the z disc to m line
Titin
Which structural protein stabilizes thick filament?
titin
Which muscle protein gives muscle its elasticity and extensibility?
Titin
Which structural muscle protein helps the sarcomere return to its resting length?
Titin
Which regulatory proteins are found in thin filaments?
Tropomyosin and troponin