Unit 3 - Blood PART A & B Flashcards
Blood
is a connective tissue that is specialized for transport and exchange solutes and fluids
Blood consists of:
a. Plasma – suspension of water and solutes
b. Formed elements – cells
Volume is ~_ to _ liters in MEN, and ~_ liters in WOMEN (dependent on body size)
5
5.5
4
Plasma
- makes up 1/4 of the ECF, the internal envir. that bathes cells & acts as a buffer b/t cells & the external envir.
- fluid matrix of the blood, within which cellular elements are suspended
- identical in composition to IF except for the presence of PLASMA PROTEINS
Plasma composed of:
a. Water (~90%)
b. Dissolved solutes, including:
i. Proteins
ii. Electrolytes
iii. Nutrients
iv. Gasses
v. Metabolic waste products (e.g. urea, creatinine)
How much % does WATER in plasma contribute?
~90%
What do the dissolved solutes in plasma include?
i. Proteins
ii. Electrolytes (e.g. Na+, Cl-, H+, K+, Ca2+, HCO3-)
iii. Nutrients (e.g. glucose, amino acids, lipids, vitamins)
iv. Gasses (e.g. O2, CO2, N2)
v. Metabolic waste products (e.g. urea, creatinine)
Proteins (within the dissolved solutes of plasma)
determines…
determines plasma colloid osmotic pressure (πC ) and can
act as a buffer to help maintain blood pH.
Proteins (within the dissolved solutes of plasma) includes:
- Albumins
- Globulins
- Fibrinogen
- Transferrin
- Peptide/Protein Hormones
Albumins
60% of all proteins; primarily responsible for πC
Globulins
α, β globulins transport lipids, some metal ions and
hormrones; γ (gamma) globulins (immunoglobulins/antiboidies).
Immunoglobulins/antiboidies (within globulins)
syn. & secreted by SPECIALIZED BLOOD CELLS rather than by the liver
Fibrinogen
clotting protein
Transferrin
transports iron that is not part of hemoglobin
What makes most plasma proteins & secretes them into the blood?
LIVER
Electrolytes (within the dissolved solutes of plasma)
e.g. Na+, Cl-, H+, K+, Ca2+, HCO3-
Nutrients (within the dissolved solutes of plasma)
e.g. glucose, amino acids, lipids, vitamins
Gasses (within the dissolved solutes of plasma)
e.g. O2, CO2, N2
Metabolic waste products (within the dissolved solutes of plasma)
e.g. urea, creatinine
Presence of _____ in the plasma makes the osmotic pressure of the blood ______ than that of the IF. Explain
PROTEINS
HIGHER
- this osmotic gradient tends to pull water from the IF into the capillaries & offset filtration out of the capillaries created by BP