unit 2 Flashcards
innate immunity
responds nonspecifically to their target
broad
we are born with innate immunity
adaptive immunity
highly specific recognition of pathogen
takes time to develop
generates memory
inflammation moves which cells form the blood to the site of infection
WBCs
Th1 cells activate
macrophages and CD8+ T cells
Th2 cells activate
B cells
cytotoxic T cells
bind cells, make holes (perforin) and kill (granzymes)
plasma cells
B cells differentiate into plasma cells
make and secrete Abs
humoral immunity
extracellular
* B cells (plasma cells)
cell-mediated immunity
intracellular
* CD4+ and CD8+ cells
what types of antigens activates B cells independently of T cells
polysaccharides, typically from capsules
IgM
activates complement
IgG
most abundant Ab in serum
crosses placenta
opsonization
which Ab is generated first and which antibody is produced after B cells class switch?
IgM then IgG
toxoid vaccine
contain inactivated exotoxin
conjugate vaccine
polysaccharides linked to proteins, enhance antigenicity in young children