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hellma lec > UNIT 1.2 STEM CELLs > Flashcards

UNIT 1.2 STEM CELLs Flashcards

1
Q

HEMATOPOIETIC STEM CELLS are capable of

A

○ Self-renewal,
○ Pluripotent
○ Give rise to differentiated progeny

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2
Q

megakaryocyte becomes

A

platelets

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3
Q

T lymphoblast becomes

A

T cell

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4
Q

B lymphoblast becomes

A

B cell

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5
Q

Respond best to multiple cytokines

A

PROGENITOR CELLS

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6
Q

much
more mature than progenitor cells

A

PROGENITOR CELLS

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7
Q

all blood cells are derived
from a single progenitor stem cell

A

MONOPHYLETIC THEORY

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8
Q

pre-T becomes

A

T lymphoblast

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9
Q

Progeny increasingly acquire specific differentiation markers and function

A

PROGENITOR CELLS

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10
Q

megakaryoblast becomes

A

megakaryocyte

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11
Q

pronormoblast becomes

A

erythrocyte

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12
Q

Are multipotent

A

PROGENITOR CELLS

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13
Q

megakaryocyte-erythrocyte progenitor becomes

A
  • pronormoblast
  • megakaryoblast
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14
Q

each of the blood cell lineages
is derived from its own unique stem cell

A

POLYPHYLETIC THEORY

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15
Q

pre-B becomes

A

B lymphoblast

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16
Q

myeloblast becomes

A
  • neutrophil
  • eosinophil
  • basophil
17
Q

Blast cells committed to unilinear differentiation

A

PRECURSOR CELLS

18
Q

Do not self-renew or have only an extremely limited
capacity

A

PROGENITOR CELLS

19
Q

Common myeloid progenitor becomes

A
  • granulocyte-monocyte progenitor
  • eosinophil-basophil progenitor
  • megakaryocyte-erythrocyte progenitor
  • mast cells
20
Q

granulocyte-monocyte progenitor becomes

A
  • myeloblast
  • monoblast
21
Q

Hematopoietic stem cells become

A
  • Common myeloid progenitor
  • common lympoid progenitor
22
Q

HEMATOPOIETIC STEM CELLS Fates:

A

○ Self-renewal
○ Differentiation
○ Apoptosis

23
Q

still replicate until near terminal differentiation

A

PROGENITOR CELLS

24
Q

eosinophil-basophil progenitor becomes

A

myeloblast

25
Q

common lympoid progenitor becomes

A
  • dendritic cell
  • Pre-B
  • Pre-T
  • Natural killer cells
26
Q

HEMATOPOIESIS have Unique interactions of:

A
  1. Pluripotential SC/ (HSC)
  2. Microenvironment
  3. Cytokines/Growth Factors
    a. Colony-stimulating factor
    b. Kit Ligand/Stem Cell Factor
    c. Interleukins
  4. EPO
  5. TBO (thrombopoietin)
27
Q

B cell becomes becomes

A

Plasma cells

28
Q

Respond best to one or 2 cytokines

A

PROGENITOR CELLS

29
Q

Do not self-renew

A

PROGENITOR CELLS

hellma lec (12 decks)

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