UNIT 1.2 PRENATAL HEMATOPOIESIS Flashcards
Hepatic period site
Fetal Liver
Occurs intravascularly
Mesoblastic period
when does BM
becomes the primary site
By the end of 24th weeks of gestation
only initiate the production of red
blood cells if the bone marrow stops functioning.
extramedullary hematopoiesis
two primary hematopoietic organs in leukopoiesis, especially in lymphopoiesis
- bone marrow
- thymus
3 stages/periods of prenatal hematopoiesis:
- Mesoblastic period
- Hepatic period
- Myeloid/Medullary period
Hepatic period happens during
5th to 7th gestational week
Myeloid/Medullary period site
medulla of BM
the RBCs contain unique fetal hemoglobins :
○ Gower 1
○ Gower 2
○ Portland
Sites of blood cell formation and circulation during MYELOID/MEDULLARY PERIOD
○ Epiphysis of the Long Bone
○ Flat Bones: Red Marrow
in fetal development, contributory to the release of EPO are the ________ and _____
liver and kidneys
hormone Necessary for the development in
production of red blood cells
Erythropoietin (EPO)
hormone that Initiates white blood cells production
Granulocyte Colony Stimulating Factor
(G-CSF), Granulocyte Monocyte Colony
Stimulating Factor (GM-CSF)
other name for mesoblatic period
Primitive Erythropoiesis
Extramedullary organs:
- liver
- spleen
- thymus
- lymph nodes
Occurs extravascularly
HEPATIC PERIOD
Site of mesoblastic period
yolk sac of the embryo
MYELOID/MEDULLARY PERIOD begins at
4th to 5th month of fetal development
when does mesoblastic period happen
19th day after fertilization
s the stimulus that would initiate the release of EPO in the kidneys targeting the bone marrow to produce RBCs
Hypoxia
Megakaryopoeisis begins
Hepatic period
MYELOID/MEDULLARY PERIOD have detectable leveles of:
- Erythropoietin (EPO)
- Granulocyte Colony Stimulating Factor (G-CSF)
- Granulocyte Monocyte Colony
Stimulating Factor (GM-CSF)
HEPATIC PERIOD Hemoglobin:
○ Fetal hemoglobin
○ HbA
○ HbA2
n a newborn, all the bone marrow is ________, and all of it is
involved in red blood cell production
red marrow
