UNIT 1 - Lecture 14: Leukemias

Question 1

What is leukemia?

Answer 1

Neoplastic cells of hematopoietic origin in blood and or marrow

Question 2

Leukemia can be of what origins?

Answer 2

Erythroid, granulocytic, monocytic, megakaryocytic, lymphoid

Question 3

What are the terms acute and chronic used for in leukemia?

Answer 3

Related to differentiation/maturity (not duration)

Question 4

What is needed to tell the cell of origin of acute leukemia?

Answer 4

Immunophenotyping (cannot tell on smear)

Question 5

What leukemia type is more aggressive?

Answer 5

acute

Question 6

In chronic leukemia, the cell of origin is _____.

Answer 6

well-differentiated

Question 7

Which type of leukemia is more indolent?

Answer 7

chronic

Question 8

What is lymphoma?

Answer 8

Neoplasm arising from extramedullary lymphocytes (i.e. LNs, spleen, etc.)

Question 9

When can lymphocytes not be differentiated from an cute leukemia?

Answer 9

When they are large and poorly differentiated.

Question 10

What is the most common type of chronic leukemia in dogs?

Answer 10

Chronic lymphocytic leukemia

Question 11

What age dogs are usually affected with chronic lymphocytic leukemia?

Answer 11

middle aged to older

Question 12

Chronic lymphocytic leukemia can cause a persistent _____ in dogs.

Answer 12

lymphocytosis

Question 13

Of what cell origins can chronic lymphocytic leukemia be?

Answer 13

T, B, or NK cell

Question 14

What are 5 rare and chronic myeloproliferative disorders?

Answer 14

1. Primary absolute erythrocytosis
2. Essential thrombocythemia
3. Chronic neutrophilic leukemia
4. Chronic eosinophilic leukemia
5. Chronic basophilic leukemia