UNIT 1 - Lecture 10: Monocytes, Lymphocytes, Eosinophils, Basophils Flashcards
What two “pools” do monocytes have in circulation?
circulating and marginating
Which line of defense are monocytes?
second line
When do monocytes come into tissues?
After NPs “clean up” debris as a MP
What are monocytes that marginate then emigrate into tissues classified as?
“short lived”
What are monocytes that are residents in organs classified as? What are the AKA?
“long lived” = macrophages
What is an increase in the circulating monocyte pool called?
monocytosis
What is inflammatory monocytosis associated with?
Non-acute to chronic inflammation (>7-10 days)
What species have corticosteroid monocytosis?
dogs
(sometimes cats)
What is a decrease in monocytes called and when is it seen?
monocytopenia;
rarely seen, often of no clinical significance
(all WBC lines may be decreased in the bone marrow
Where do B cells mature?
In the bone marrow
What type of tissues are B cells found in and what are the specific tissues?
Peripheral lymphoid tissues;
Spleen, LNs, MALT, GALT, BALT
Where do T cells mature?
Thymus
In what tissues are T cells found?
Peripheral lymphoid tissue - effector cells
Where do lymphocytes circulate?
Between blood, tissues, and lymphoid tissue via blood and lymphatics
T/F: Microscopic appearance cannot differentiate monocyte subsets (B cells vs. T cells)
True
How can you differentiate between B and T cells in peripheral blood?
ID surface Rs and/or lymphocyte clonality (flow cytometry or PCR for Ag R rearrangement)
What are the 5 main causes for lymphocytosis?
- Physiologic
- Antigenic stimulation
- Inflammation
- Lymphoproliferative disease
- Lack of glucocorticoids
What are physiologic causes for lymphocytosis?
Epinephrine/catecholamine
What is an example of lymphoproliferative disease that causes lymphocytosis?
lymphoid neoplasia
What is an example of lack of glucocorticoids causing lymphocytosis?
Addison’s
How does epinephrine cause lymphocytosis?
Increases blood flow rate, shifts MLP to CLP
When can we see lymphocytosis in health?
Common in young animals
In some spp, the RI results for lymphocytosis in health may be the result of _____ and _____.
sampling, epinephrine release
How can antigenic stimulation cause lymphocytosis?
There is chronic cytokine stimulation, altered lymphocyte circulation, lymphoid hyperplasia, and reactive lymphocytes
