Ulcerative Colitis

Question 1

Which race does Ulcerative colitis affect?

Answer 1

Caucasians in temperate climates

Question 2

How common is Ulcerative Colitis?

Answer 2

2-3 times more common the Crohn’s

Question 3

What age group does Ulcerative colitis affect?

Answer 3

Young people but can occur in children and the elderly

Question 4

Describe the pathology of UC

Answer 4

There is continuous inflammation
Inflammation is confined to the rectum and colon
The inflammation is confined to the mucosa and submucosa

Question 5

Describe what causes UC?

Answer 5

This is the result of an environmental trigger in a genetically susceptible individual

Question 6

Symptoms of UC?

Answer 6

Bloody Diarrhoea
Mucous in stool
Tenesmus
General Malaise
Anorexia
Clubbing
Liver Failure

Question 7

Describe an acute attack of UC

Answer 7

Diarrhoea twenty times a day
Fever
Tachycardia

Question 8

Treatment of UC?

Answer 8

5- ASA (Mesalazine)
Steroids (Prednisolone)
Immunosuppresants (Aziothioprine)
Anti-TNF Therapy (Infliximab)
Surgery (Total Colectomy)

Question 9

Examinations for UC?

Answer 9

PR Exam
Stool Sample
AXR
FBC
Colonoscopy

Question 10

Complications of UC?

Answer 10

Perforation
Bleeding
Toxic Megacolon
Colon Cancer

Question 11

In what circumstances would UC lead to cancer?

Answer 11

If the patient has had UC for more than 10 years`

Question 12

Describe the histology of UC

Answer 12

Inflammatory Cell Infiltrate
Crypt Abscesses
Cryptitis
Superficial Ulceration 
No fistulae
No granulomas

Question 13

What is the Prognosis for UC?

Answer 13

Remission
Chronic Disease
Mixture of both –> Remission, Relapse, Remission, Relapse

Question 14

Name of a 5-ASA?

Answer 14

Mesalazine

Question 15

Name of a steroid?

Answer 15

Prednisolone

Question 16

Name of an immunosuppresant?

Answer 16

Aziothioprine

Question 17

Name of Anti-TNF Therapy?

Answer 17

Infliximab