Uge 47 - The humoral immune response Flashcards

1
Q

Hvad bidrager antibodies til

A

Neutralization, opsonization og complekemnt aktivering

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2
Q

Naive B celler har brug for ….. for at kunne blive aktiveret

A

acessory signaler fra enten helper T celler eller direkte fra mikrobiale elementer

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3
Q

T FH celler har en ligand der kan binde til hvad på B celler

A

CD40

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4
Q

Når T FH celler binder med B celler producere de

A

cytokiner som IL-21

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5
Q

CD aktivere

A

non-canonical NFkB pathway

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6
Q

Hvad er TI antigener

A

Antigener der kan skabe antibodies uden T celler (Thymus independent)

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7
Q

Hvad indeholder B-celle co-receptore complekser

A

CD19, CD21 og CD81

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8
Q

Hvor i germinal center mutere B celler deres antibodies

A

Dark zone

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9
Q

Hvad er somatisk hypermutation

A

Når der laves mutationer i immunoglobulins variable regioner for at skabe højere affinitet for antigener

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10
Q

Hvad gør AID

A

Starter hypermutationen, ved at deaminere cytosiner i den variable region på et immunoglobulin lokus i DNA’et

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11
Q

Hvilket immunoglobulin antibodie frigiver B celler først

A

IgM

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12
Q

Hvilke antibodies binder Mast celler og basophils

A

IgE (mastceller kan også genkende IgG)

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13
Q

Antibody coated patogene genkendes af effektor celler gennem hvilken receptor

A

Fc receptor

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