Uge 39 - Innate imunity - the first lines of defense

Question 1

Lysozyme

Answer 1

Glycosidase der bryder specifikke bond i peptidoglycan

Question 2

Antimicrobial peptider

Answer 2

Defensins, Cathelicidins, Histatins, Lecticidins

Question 3

Amphiphatic

Answer 3

A molecule that has both hydrophobic and hydrophilic regions.

Question 4

Defensins

Answer 4

Kan indsættes i cellemembranen og danne porrer

Question 5

Complement pathways

Answer 5

classical, lectin, alternative

Question 6

zymogens

Answer 6

inaktiv proenzyme

Question 7

komplementære protein række

Answer 7

C1-C4-C2-C3-C5-C6-C7-C8-C9

Question 8

PAMP

Answer 8

pathogen associated molecular patterns. examples include dsRNA and viral proteins

Question 9

Lectin pathway receptors

Answer 9

mannose-binding lectin MBL og ficolins

DEr dannes et MBL-MASP kompleks

Question 10

classical and lectin C3 convertase

Answer 10

C4b2a

Question 11

classical pathways pathogen sensor

Answer 11

C1 - Kan interagere med patogen eller antibodies

Question 12

The alternativ pathway C3 convertase

Answer 12

C3bBb og C3(H2O)Bb

Stabiliseres ved at binde factor P (properdin)

Question 13

C3 convertaser kløver

Answer 13

C3 til C3b og C3a

Question 14

C3b binder til

Answer 14

den patogene overflade

Question 15

C5 convertase

Answer 15

Binding of C3b to both C4b2a and C3bBb

Enzyme complex that cleaves C5 to C5a and C5b.

Question 16

CR

Answer 16

complement receptor på makrofag

Genkender C3b.

Når C5a også er til stede vil der ske phagocyotse.

Question 17

Hvad gør C6-C7-C8 og C9

Answer 17

C5b trigger C6, C7 og C8, som sætte sig på cellemembranen. Så kommer C9 og danner en porre.