Uge 41 - Antigen genkendelse Flashcards

1
Q

Hvor sidder de varierende dele i B-celle receptoren/antistoffet

A

I loops mellem betastrands

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2
Q

Hvilket kræfter binder antigenet til antistoffet

A

Elektrostatiske, hydrogen binder, van der waals kræfter, hydrofobiske kræfter, cation pi interaktioner

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3
Q

Hvor mange antigener kan et antistof binde

A

2

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4
Q

Hvad hedder det protein i B-celler som genkender antigener

A

Immunoglobulin (Ig)

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5
Q

Hvor mange Ig klasser er der og hvilke

A

Fem: IgM, IgG, IgD, IgA, IgE

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6
Q

Hvilket to funktion har antistoffer

A

Binde patogene og rekruttere andre celler/molekyler

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7
Q

Hvad står den variable og den konstante del for

A

Variabel: binde til patogen

Konstante: tilkaldes værtens egne celler/proteiner

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8
Q

Hvad genkender T-celle receptoere

A

Peptidfragmenter der udstilles på værtens egne celler på deres MHC komplekser

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9
Q

Hvilken del af antistoffet binder med antigenet

A

CDR

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10
Q

Hvad hedder den struktur der genkendes af et antistof

A

antigenic determinant/epitop

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11
Q

MHC I

A

molecules found on every body cell that presents antigen; signals cytotoxic T to destroy

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12
Q

MHC II

A

molecules found on macrophages, B cells, and activated T cells; signal helper T cells

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13
Q

CD4

A

Udtrykkes af hjælper T-celler

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14
Q

CD8

A

Udtrykkes af cytotoksiske celler.

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15
Q

Hvilket regioner består light chain af

A

V,J og C

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16
Q

Hvilket regioner består heavy chain af

A

V,D, J og C

17
Q

Hvordan sættes V, D , J segmenterne sammen

A

Via somatisk rekombination

18
Q

RSS

A

recombination signal sequences

DNA sekvenser der guider sammensætningen f V, D og J segmenter, så de sættes rigtig sammen