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General Pathology > Ubiquitin-Proteasome System In Disease > Flashcards

Ubiquitin-Proteasome System In Disease Flashcards

1
Q

Lewy bodies (a-synuclein)

A

Parkinson disease, decreased activity

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2
Q

Amyloid plaques, neurofibrillary tangles

A

Alzheimer disease, decreased

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3
Q

Superoxide dismutase aggregates in motor neurons

A

Amyotrophic lateral sclerosis, decreased

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4
Q

Polyglutamine inclusions

A

Huntington disease, decreased

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5
Q

Chronic inflammation

A

Sjogren syndrome, decreased

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6
Q

Insulin sensitivity

A

DM Type 2, increased

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7
Q

Aggregated oxidized proteins

A

Cataract formation, decreased

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8
Q

Atrophy

A

Aging and cancer and other chronic disease, increased

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9
Q

Myocyte apoptosis

A

Ischemia/repurfusion, pressure overload, decreased

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General Pathology (8 decks)

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