u7: kidneys Flashcards
GFR and renal clearence
gfr= 125
if RC> GFR= SECRETED (LOWER= REABSORBED)
RC=0 then drug not present
what increase GFR vs dec
paracrine postaglandins (dilate)
up permeability of glomrtulud
up SA glomerulus
up podcyte decrease gfr (since vasocon), also NE and E and afferent
normal urine components
water, urea, creatinine, uric acid, ions
not normal if theres
protein, glu, blood, or ketones
psns role in micturition
contracts SM wall of bladder,
relaxes internal sphincter (not voluntary)
constriction of only efferent arteriole
inc GFR (if both afferent and efferent then decrease gfr)
external sphincter can be controlled but is overide at..
autoregulation can dail at mean arterial p
500ml
higher than 180 mmhg
SGLUT
use NA grad ti transport glu into cell, glu exits out basolateral side (enters in apical)
sodium reabsorption
rmbr NA-K atpase pumps in basolateral membrane (out) not apical membrane
they are involved in absorption of AA (also cl, and water), allows Na to diffuse into tubule cells. are mainly in proximal tubule
intrinsic autoregulation
myogenic= more pressure= constricts
macula densa= senses na= release signals= afferent constricts
how is gfr not the only way to control ion blood balance
Glomerular filtration starts the process, but reabsorption and secretion are critical for precise control of blood volume
blood flows from afferent arterioles directly to peritubular cap
false (into glomerulus first, then efferent, then peritubular)
filtrate does not contain
platelets and protein
filtration barrier in the glomerulus prevents large molecules like proteins and rbc
