U3.2 - Blood and Tissue Flagellates Flashcards
Flagellates that are found in the blood and other fluids (CSF) and in tissues
blood and tissue flagellates
Blood and tissue flagellates:
what kind of parasites
vector-borne
Blood and tissue flagellates:
Medically important genera
- Trypanosoma
- Leishmania
Blood and tissue flagellates:
MOT
Transmitted by a bite of an infected vector
Blood and tissue flagellates:
four morphological forms
- Amastigote – (Donovan Leishman)
- Promastigote – (Leptomonas)
- Epimastigote – (Crithidia)
- Trypomastigote
Blood and tissue flagellates:
All forms are found in?
Trypanosoma cruzi infections
Blood and tissue flagellates:
diagnostic stages
- trypomastigote
- epimastigote
- promastigote
- amastigote
Only the _____________ and _______________ are seen in Trypanosoma brucei infections
epimastigote
trypomastigote
Only the _____________ and _____________ are seen in Leishmania infections
amastigote
promastigote
Diagnostic Stages:
found in humans
amastigote and or trypomastigote
Trypanosoma cruzi:
Causative agent of?
Chagas disease or American trypanosomiasis
Trypanosoma cruzi:
habitat
- RES
- cardiac muscle
- CNS
Trypanosoma cruzi:
Intermediate host Vector
Reduviid Bug (kissing bug)
Trypanosoma cruzi:
MOT
- Feces of vector entering bite wound
- blood transfusion
- organ transplants
- transplacentally
Trypanosoma cruzi:
diagnostic stages in human body parts
- Trypomastigotes: bloodstream
- Amastigotes: tissue cells
Trypanosoma cruzi:
acute phase pathogenesis
- Non specific S/S: fever, malaise, nausea, vomiting, lymphadenopathy, cutaneous inflammation
- Chagomas
- Romaña’s sign
Trypanosoma cruzi:
chronic pathogenesis
Enlargement of vital organs (myocardium, megaesophagus)
Trypanosoma cruzi:
acute phase diagnosis
- Thick and thin blood smear using Giemsa
- CSF, tissue samples, lymph examination
- Concentration methods
- Blood culture
- PCR
- Xenodiagnosis
Trypanosoma cruzi:
chronic diagnosis
- ELISA
- Indirect hemagglutination
- Indirect immunofluorescence
- PCR
Trypanosoma cruzi:
acute phase treatment
- Nifurtimox
- Benznidazole