typical antipsychotics A01

Question 1

when were they developed?

Answer 1

in the 1950s

Question 2

what do typical antipsychotics do?

Answer 2

reduce the effects of dopamine leading to a reduction of symptoms of sz

Question 3

typical antipsychotics are dopamine…. what?

Answer 3

antagonists

Question 4

what does it mean by dopamine antagonists?

Answer 4

they bind to D2 receptors and blocking their action which eliminates positive symptoms of sz.

Question 5

in what pathway do they reduce the stimulation of dopamine?

Answer 5

mesolimbic

Question 6

what did the effectiveness of the dopamine antagonists lead to?

Answer 6

the dopamine hypothesis

Question 7

what did Kapur estimate?

Answer 7

60-75% of the D2 receptors must be blocked for these drugs to be effective.

Question 8

what is the downside to typical antipsychotics which led to the development of atypical antipsychotics?

Answer 8

since 60-75% of the D2 receptors must be blocked in the mesolimbic pathway, a similar number in other areas of the brain must also be blocked which can lead to undesirable side effects

Question 9

what may be harmful to an individual through using typical antipsychotics?

Answer 9

blocking dopamine receptors in other pathways of the brain, not just the mesolimbic pathway.

Question 10

what did this problem lead to?

Answer 10

the development of atypical antipsychotics