Typical Antipsychotics Flashcards
MOA of typical antipsychotics
block D2 dopamine receptors
What are two low potency antipsychotics?
- chlorpromazine
- Thioridazine
*may rarely cause agranulocytosis
What is the trade off in side effects of low potency?
Higher incidence of anticholinergic and antihistaminic side effects, but lower incidence of EPS and NMS.
*also slightly higher seizure risk (low potency means dose has to be higher)
What are 3 side effects that can be seen with chlorpromazine specifically?
- Orthostatic hypotension (common)
- Bluish skin discoloration
- Photosensitivity
- also deposits in lens and cornea
* can treat N/V as well as intractable hiccups
What AE is thioridazine associated with?
retinitis pigmentosa - is irreversible
What are the 4 mid potency typical antipsychotics?
- Loxapine
- Thiothixene
- Trifluoperazine
- Perphenazine
Which of the mid potency typical has highest risk of seizure?
Loxapine - has a metabolite amoaxapine that is a TCA
Which mid potency can cause ocular pigment changes?
Thiothixene
Which mid potency can reduce anxiety?
Trifluoperazine
What three drugs are high potency typical?
- Haloperidol
- Fluphenazine
- Pimozide
What high-potency has the greatest risk of CV AEs?
Pimozide - can cause heart block, v-tach among others
What two typical are available in decanoate form?
Haloperidol and Fluphenazine - given IM also to treat acute agitation or psychosis
The positive symptoms of schizophrenia are caused by DA action in the ________ DA pathway
Mesolimbic - this includes the nucleus accumbens, the fornix, amygdala, and hippocampus
The negative symptoms of schizophrenia are due to DA action in the _________ pathway.
Mesocortical
EPS are due to blocking DA in the __________.
Nigrostriatum
