SSRIs

Question 1

How long should a patient be on an antidepressant before changing the drug?

Answer 1

Around 1-2 months, at full dose

Question 2

MOA of SSRI

Answer 2

inhibit presynaptic serotonin pumps that repute serotonin

Question 3

Which SSRI is safe in pregnancy and approved for use in children ?

Answer 3

Fluoxetine

Question 4

What is the SSRI only approved for use in OCD?

Answer 4

Fluvoxamine

*nausea and vomiting more common

Question 5

Whch has the highest incidence of GI disturbances (nausea and diarrhea)

Answer 5

Sertraline

Question 6

Which has the longest half life, so there is no need to taper?

Answer 6

Fluoxetine

Question 7

Which drug is highly protein bound and therefore has many drug interactions?

Answer 7

Paroxetine

Question 8

Which has fewest drug-drug interactions and fewer sexual side effects, but higher risk of QTc prolongation?

Answer 8

Citalopram

Question 9

Which has the highest risk of withdrawal phenomena?

Answer 9

Paroxetine (shortest half life)

Question 10

Which would worst to give for someone concerned with weight gain, sedation, dry mouth?

Answer 10

Paroxetine

highest anticholinergic

Question 11

Which SSRI can elevate levels of neuroleptics?

Answer 11

Fluoxetine

Question 12

Black box warning for SSRIs

Answer 12

Increased suicidality in children and adolescents

Question 13

What are seven general side effects of SSRI

Answer 13

1. Sexual (anorgasmia, decreased interest)
2. GI (nausea, diarrhea)
3. Insomnia, vivid dreams
4. HA
5. Anorexia, weight loss
6. Restlessness (akathisia-like when going on and stopping)
7. Seizures (0.2% so low, but possible)

Question 14

Which is the only SSRI approved for bulemia nervosa?

Answer 14

Fluoxetine