Anxiolytics - benzodiazepines

Question 0

What are two long acting benzos?

Answer 0

1. Diazepam

2. Clonazepam

Question 1

Benzo MOA?

Answer 1

Potentiate the effects of GABA by allosterically binding to the receptor

Question 2

Uses of diazepam?

Answer 2

EtOH detox, seizure

not as commonly used for anxiety anymore

Question 3

Clonazepam uses?

Answer 3

anxiety including panic attacks

Question 4

In what patients must clonazepam be avoided?

Answer 4

Those with renal dysfunction

Question 5

What are the two short acting benzos?

Answer 5

1. Triazolam (no longer used)
2. Midazolam

*both are/were used primarily in medical and surgical conditions, not generally prescribed

Question 6

Which three of the intermediate benzos are used in chronic alcoholics/ liver disease b/c they are not metabolized by the liver?

Answer 6

1. Lorazepam
2. Oxazepam
3. Temozopam

• i drank a “LOT”

Question 7

Drug used for benzo overdose?

Answer 7

Flumazenil

Question 8

What are 4 AE of benzos?

Answer 8

1. drowsiness
2. impairment of intellectual function
3. reduced motor coordination
4. anterograde amnesia

Question 9

What is the toxicity of benzos/ what can happen with withdrawal?

Answer 9

Respiratory depression with overdose, esp when combined with alcohol
Withdrawal can lead to seizures and be life threatening