Non-Benzo Hypnotics

Question 0

MOA of the non benzo hypnotic?

Answer 0

Selective receptor binding to BNZ receptor 1, which is responsible for sedation

Question 1

What are three non-benzo hypnotics usually used for sleep?

Answer 1

1. Zolpidem
2. Zaleplon
3. Eszopiclone

Question 2

What is the indication to use zolpidem, zaleplon or eszoplicone?

Answer 2

Short term use as sleep aid. Not as much issue with tolerance/dependance, but can still happen.

Question 3

Order of half-life from shortest to longest

Answer 3

Zaleplon < Zolpidem < eszopiclone

Question 4

4 side effects of the non benzo drugs?

Answer 4

1. anterograde amnesia
2. hallucinations
3. sleepwalking
4. GI side effects (most common)

Question 5

What is the MOA of Ramelteon? Benefit of using?

Answer 5

selective melatonin MT1 and MT2 agonist

*no tolerance or dependence

Question 6

What is MOA of buspirone?

Answer 6

partial agonist of the 5HT-1A receptor

*does not potentiate the CNS effects of alcohol so is safe for alcoholics; also not as high risk for abuse as benzos, but takes 1-2 weeks to work

Question 7

What drug is buspirone given with commonly for anxiety and why?

Answer 7

Not as effective, so often used with SSRI

Question 8

Other than buspirone, what would be a good anti-anxiolytic to give someone that cant take benzos?

Answer 8

Hydroxyzine - is an anthistamine and has anticholinergic effects