Typical Antipsychotics

Question 0

Typical antipsychotic
Causes orthostatic hypotension
Bluish discoloration
Photosensitivity 
Can treat N V intractable hiccups

Answer 0

Chlorpromazine Thorazine

Question 1

First gen typicals low potency

Answer 1

Block D2
All have similar efficacy but differ in potency (action on d2 receptor)
Anticholinergic and antihistamine SE
Lower incidence of EPS and NMS
More lethal due to prolonged QTc and heart block leading to vent tachy
Rare agranulocytosis
Slightly higher seizure than high potency
Chlorpromazine and thioridazine

Question 2

Typical antipsychotic

Associated with retinitis pigmentosa

Answer 2

Thioridazine

Question 3

Mid potency typicals

Answer 3

Loxapine loxitane
Thiothixene navane
Trifluoperazine stelazine
Perphenazine trilafon

Question 4

Mid potency typical
High risk seizure
Metabolite is antidepressant

Answer 4

Loxapine loxitane

Question 5

Mid potency typical

Ocular pigment changed

Answer 5

Thiorhixene navane

Question 6

Mid potency typical

Reduce anxiety

Answer 6

Trifluoperazine stelazine

Question 7

High potency typicals

Answer 7

Greater affinity for dopamine receptor so only low dose
Less Sedation, orthostatic hypo, anticholingeric
Greater risk of extra pyramidal symptoms and tardive dyskinesia
Haloperidol, fluphenazine, pimozide

Question 8

Acute agitation or psychosis

Answer 8

High potency neuroleptics injectable form

Question 9

Long acting intramuscular typicals

Answer 9

Haloperidol and fluphenazine

Question 10

High potency typical
Heart block
Vent tachy
Cardiac SE

Answer 10

Pimozide oral

Question 11

Mesolithic pathway

Answer 11

Nucleus accumbens
Fornix
Amygdala
Hippocampus

Question 12

Negative symptoms

Answer 12

Mesocortical pathway

Question 13

Positive symptoms

Answer 13

Mesolimbic

Question 14

Extra pyramidal symptoms

Answer 14

Nigrostruatum

Question 15

Hyperprolactinemia

Answer 15

Tuberoinfundibular

Question 16

Antidopaminergic

Answer 16

Parkinsonism
Akathisia- a anxiety restlessness fidget
Dystonia- painful contractions of neck(torticollis) eyes. Lethal w diaphragm

Question 17

Hyperprolactinemia

Answer 17

Decreased libido, galactorrhea, gynecomastia, impotence, amenorrhea, osteoporosis

Question 18

Tardive dyskinesia

Answer 18

Choreoathetoid movements of mouth and tongue >6 months
Older women
50% remit
Stop antipsychotic
1% per year

Question 19

Neuroleptic malignant syndrome

Answer 19

Rate
Males early in treatment
20% mortality
FALTERED
Stop med
Supportive cooling and hydration

Question 20

FALTERED

Answer 20

Fever
Autonomic instability
Leukocytosis
Tremor
Elevated CPK
Rigidity lead pipe
Excessive sweating
Delirium

Question 21

Treating extra pyramidal SE

Answer 21

Reduce antipsychotic
Anticholingeric Benzotropine
Antihistamine diphenhydramine
Antiparkisons amantadine