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PsychPharm > SSRIs + Side Effects > Flashcards

SSRIs + Side Effects Flashcards

0
Q

Hypotension

A

Antiadrenergic

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1
Q

Sedation, weight gain

A

Antihistamine

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2
Q

Dry mouth, blurry vision, intimacy retention.

A

Antimuscarinics

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3
Q

Confusion, flushing, diaphoresis, tremor, myoclonus jerks, hyperthermia, hypertonicity, rhabdo, renal failure, death, delirium, electric jolt limb

A

Serotonin Syndrome

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4
Q

SSRI +MAOI

A

Serotonin syndrome

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5
Q

MAOI + Tyramine

A

Hypertensive crisis

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6
Q

Restlessness and agitation

A

Akathisia

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7
Q

Sustained contraction of muscles of neck, tongue, eyes, diaphragm, able normal postures

A

Dystonia

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8
Q

Parkinsonism, Akathisia, Dystonia
Within days of starting med
Life threatening

A

High potency antipsychotics

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9
Q

Hyperprolactinemia

A

Traditional antipsychotics and risperidine

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10
Q

Choreoathetoid muscle movements of mouth and tongue, tongue protrusion

A

Years of high potency typical antipsychotics aka tardive dyskinesia

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11
Q

Fever, tachycardia, HTN, tremor, increased CPK, lead pipe rigidity.

A

Neuroleptic malignant syndrome

All antipsychotics after short or long time

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12
Q

Smoking
Carbamazepine
Barbiturates
St johns wort

A

CYP450 inducers
Increased metabolism
Lower drug level

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13
Q

Extra pyramidal side effects treatment

A

Benzotropine

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14
Q 
Fluvoxamine
Fluoxetine
Paroxetine
Duloxetine
Sertraline
A

CYP450 inhibitors
Prevents metabolism
Increase drug levels

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15
Q

All antidepressants have…

A

Similar response rates for major depression but different side effect profiles and safety.
70% respond, 30% is placebo
3-4 weeks to take effect
Withdrawal phenomenon (dizziness, headaches, nausea, insomnia, malaise).

16
Q

Exacerbate Alzheimer’s

A

Anticholinergics

17
Q

Weekly dosed SSRI

Intermittent explosive disorder

A

Fluoxetine

18
Q

Relationship between SSRI efficacy and side effects to plasma concentration

A

None

19
Q

SSRI
Long half life
Safe in pregnancy
Increase neuroleptic a

A

Fluoxetine Prozac

20
Q

SSRI
Highest risk of GI upset
Few drug interactions
Sleep changes

A

Sertraline Zoloft

21
Q 
SSRI
Highly protein bound
Several drug interactions
Antichol(sedation, constipation, weight gain)
Short half life more like withdrawal
A

Paroxetine Paxil

22
Q

SSRI
Only for OCD
Nausea vomiting
Lots of drug interactions

A

Fluvoxamine Luvox

23
Q

SSRI
Fewest drug interactions
Fewer sexual side effects

A

Citalopram celexa

24
Q

Levi-enantiomer

Fewer side effects to citalopram

A

Escitalopram lexapro

25
Q 
Safer in over dose
Sexual dysfunction (do not resolve)
GI, insomnia, headache, anorexia, restlessness at initiation and termination
A

SSRI Side effects

26
Q

SSRI plus cough syrup or triptans

A

Serotonin syndrome

PsychPharm (15 decks)

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