Heterocyclic Antidepressants

Question 0

TCA

chronic pain, migraines, insomnia

Answer 0

Amitriptyline elavil

Question 1

Inhibit reuptake of norepinephrine and serotonin

Rarely used first because of side effects and overdose potential

Answer 1

TCAs

Question 2

TCA
Intramuscular
Enuresis and panic disorder

Answer 2

Imipramine

Question 3

TCA
Most serotonin specific
OCD

Answer 3

Clomipramine anafranil

Question 4

TCA
Chronic pain
Emerging sleep aid

Answer 4

Doxepin sinequan

Question 5

TCA
Sedating
Anticholinergics
Lethal

Answer 5

Tertiary amines
Amitriptyline
Imipramine
Clomipramine
Doxepin

Question 6

TCA
Less anticholinergic
Less sedating

Answer 6

Secondary amines
Nortiptyline
Desipramine

Question 7

TCA
Least likely to cause orthostatic hypotension
Chronic pain

Answer 7

Nortiptyline pamelor aventyl

Question 8

TCA
More activating least sedating
Least anticholinergic

Answer 8

Desipramine norpramin

Question 9

Tetracycline
Metabolite of antipsychotic loxapine
EPS

Answer 9

Amoxapine asendin

Question 10

Tetracycline

Higher rate of seizure, arrhythmia, fatality

Answer 10

Maprotiline

Question 11

TCA side effects

Answer 11

Highly protein bound- interacts with other drugs
Antihist- sedating
Antiadrenergic- orthostatic hypotension, dizziness, reflex tachy, arrhythmias, wide qrs qt pr. Avoid in MI
Antimusc- dry mouth, constipation, urinary retention, blurred vision, tachy, exacerbation of narrow angle glaucoma
Weight gain
Lethal

Question 12

Cardiotoxicity
Convulsions
Cons

Answer 12

Complications of TCAs

Question 13

Agitation, tremors, ataxia, delirium, hypovent from cns depression, myoclonus, hyperreflexia, seizures, coma

Answer 13

TCA overdose

Question 14

Erectile and ejactulatory dysfunction in males and anorgasmia in females

Answer 14

TCAS serotonergic effects