Type III

Question 1

Immune Complex Reactions

Answer 1

• Antigen-antibody complexes formed in circulation & deposited later in vessel walls or other tissue (kidney, vessels, skin, joints)
  > IgG & IgM antibody-antigen immune complexes in circulation
• Harmful effects caused by complement cascade activation
  > attracts neutrophils
  > unsuccessful phagocytosis
  > release of lysosomal enzymes into inflamm site; incrs inflamm reaction
• EX: rheumatoid arthritis, lupus