Transplant Rejection Flashcards
1
Q
Rejection
A
- Graft v. Host
-
3 Types
> hyperacute
> acute
> chronic - Immune system recognizes tht the transplant is not its own; begins to attack
- Prevention = immune suppression
2
Q
Graft =
A
Transplant
3
Q
Host =
A
Receptacle
4
Q
Hyperacute Rejection
A
- Occurs immediately
- Antiodies react to antigens
- Complement cascade
- Blood clots & enzymes
- Inflammation
- Massive cellular destruction
5
Q
Acute Rejection
A
- 1wk - 3mnths
-
2 Mechanisms
1. antibody mediated vasculitis leads to vessel necrosis
2. cytotoxic & NK cells start inflammatory process & cellular lysis - Organ death may occur or may be medically managed
6
Q
Chronic Rejection
A
- Inflammation & scarring
- Vessel occlusion
- Chronic ischemia bc of blood vessel injury
- Specific to type of transplanted organ
- Form of graft vs hosts
7
Q
Chronic Rejection: Nursing Implications
A
-
Be aware of rejection in conjunction w/ specific transplanted material
> like renal failure in kidney transplant - Give scheduled anti-rejection medication
-
Know anti-rejection meds & side effects & therapeutic lab values
> go read book/watch VO
8
Q
Transplant: Nursing Implications
A
-
Watch for manifs of infection
> elevated temp
> elevated HR
9
Q
Transplant: Nursing Diagnosis
A
Ineffective protection r/t immunotherapy suppression
