Type IA: quinidine

Question 1

What are some other effects of quinidine?

Answer 1

• alpha adrenergic antagonism (hypotenstion)
• vagal inhibition (increase AV nodal)
• cardiac depressant action

Question 2

What is the half life of quinidine?

Answer 2

• 6-7 hours

Question 3

Is quinidine protein bound in the body, if so give an example?

Answer 3

highly protein bound; alpha-1 acid glycoprotein

Question 4

When should you use a high dose of qunidine?

Answer 4

after acute MI

Question 5

What is an interaction of quinidine?

Answer 5

its a potent inhibitor of CYT P450

Question 6

What are some non-cardiac side effects of quinidine?

Answer 6

diarrhea

cinchonism: headache, dizziness tinnituse (improves with dose reduction)

immunological reactions: hepatitis, thrombocytopenia, lupus-like syndrome, myasthenia gravis

Question 7

Why would AV blockers need to be avoided in combination with type IA drugs?

Answer 7

depress contractility

Question 8

How would qunidine impact the atrial rate and conduction?

Answer 8

slows conduction velocity in the atrium but b/c it has anticholinergic effects ventricular rate would speed up, and AV nodal conduction velocity

pretreat with digoxin with blocks AV node to manage this