Type IA: procainamide Flashcards
1
Q
What are some important features of procainamide?
A
it DOES not have alpha blocking or anticholinergic activity
2
Q
What is the half life of procainamide?
A
its 3-4 hours, need repeated dosing and sustained release formulations
3
Q
What is the metabolite of procainamide and what does it block and effect?
A
- metabolite is: N-acetyl procainamide (NAPA)
- blocks K channels
- no effect on sodium channels
- metabolite prolongs QT
4
Q
Where is the metabolite of N-acetyl-procainamide removed?
A
its eliminated by the kidney for a half life of 6-10 hours
it can induce torsades de pointes
5
Q
What are the side effects of procainamide?
A
